Obesity can profoundly alter pulmonary function and diminish exercise capacity by its
adverse effects on respiratory mechanics, resistance within the respiratory system …

Background Therapy options for OSA and central sleep apnea (CSA) are limited, thus many
patients remain untreated. Clinically, acetazolamide is sometimes used for CSA; however …

Background The treatment of choice for moderate to severe obstructive sleep apnoea (OSA)
is continuous positive airways pressure (CPAP) applied via a mask during sleep. However …

Awareness of the importance of sleep-related disorders in patients with cardiovascular
diseases is growing. In particular, sleep-disordered breathing, short sleep time, and low …

Sleep apnea syndromes are a common cause of sleepiness and neurocognitive impairment
and have been implicated as an independent risk factor for cardiovascular disease. While …

Obstructive sleep apnea syndrome (OSAS) is a frequent, albeit underdiagnosed problem in
children. If left untreated, OSAS may lead to substantial morbidities affecting multiple target …

The response to chemical stimuli (chemical responsiveness) and the increases in
respiratory drive required for arousal (arousal threshold) and for opening the airway without …

Rationale: Exogenous serotonin at the hypoglossal motor nucleus (HMN) stimulates
genioglossus (GG) muscle activity. However, whether endogenous serotonin contributes to …

The Posthumous Papers of the Pickwick Club, published in 1836. Joe was an excessively
sleepy, obese boy who snored loudly and had possible right-sided heart failure that led to …

Sleep disordered breathing (SDB), ie, obstructive, central or mixed sleep apneas, has been
recognized as a common occurrence in the elderly. Aging is per se associated with a …