Background The 2013–15 Ebola outbreak was unprecedented due to sustained
transmission within urban environments and thousands of survivors. In 2014 the World …

Ebolaviruses, discovered in 1976, belongs to the Filoviridae family, which also includes
Marburg and Lloviu viruses. They are negative-stranded RNA viruses with six known …

Ebola virus (EBOV) disease is characterized by lymphopenia, breach in vascular integrity,
cytokine storm, and multiorgan failure. The pathophysiology of organ involvement, however …

To date there are no approved antiviral drugs for the treatment of Ebola virus disease (EVD).
While a number of candidate drugs have shown limited efficacy in vitro and/or in non-human …

From the latest vaccination evidence, recommendations, and protocols... to new vaccine
development and the use of vaccines in reducing disease, Plotkin's Vaccines, 8th Edition …

Highlights•The first successful primate Ebola vaccine employed a heterologous prime-boost
genetic vaccine.•Single-shot, rapid protection correlates with serum anti-GP IgG in …

Zaire ebolavirus (EBOV), one of five species in the genus Ebolavirus, is the causative agent
of the hemorrhagic fever disease epidemic that claimed more than 11,000 lives from 2014 to …

A cornerstone of effective disaster management is that response should always begin and
end at the local level. The response to the Ebola virus disease (EVD) outbreak in Liberia …

In response to the 2014–2016 Ebola virus disease (Ebola) epidemic in West Africa, CDC
prepared for the potential introduction of Ebola into the United States. The immediate goals …

Ebola virus disease (EVD) is characterised by systemic viral replication, immuno-
suppression, abnormal inflammatory responses, large volume fluid and electrolyte losses …