Formation of the 3′ end of a eukaryotic mRNA is a key step in the production of a mature
transcript. This process is mediated by a number of protein factors that cleave the pre …

Efficient release of promoter-proximally paused RNA Pol II into productive elongation is
essential for gene expression. Recently, we reported that the Integrator complex can bind …

The elongation stage of transcription by RNA polymerase II (RNA Pol II) is central to the
regulation of gene expression in response to developmental and environmental cues in …

INTRODUCTION Factor-dependent transcription termination is essential to limit pervasive
transcription, maintain genome stability, balance the expression of neighboring genes, and …

Termination of RNA polymerase II (RNAPII) transcription in metazoans relies largely on the
cleavage and polyadenylation (CPA) and integrator (INT) complexes originally found to act …

Alternative cleavage and polyadenylation (APA) is a widespread mechanism to generate
mRNA isoforms with alternative 3′ untranslated regions (UTRs). The expression of …

Transcription progression is governed by multitasking regulators including SPT5, an
evolutionarily conserved factor implicated in virtually all transcriptional steps from enhancer …

The allosteric and torpedo models have been used for 30 yr to explain how transcription
terminates on protein-coding genes. The former invokes termination via conformational …

Based on in vitro studies, it has been demonstrated that the DSIF complex, composed of
SPT4 and SPT5, regulates the elongation stage of transcription catalyzed by RNA …

During eukaryotic transcription elongation, RNA polymerase II (RNAP2) is regulated by a
chorus of factors. Here, we identified a common binary interaction module consisting of TFIIS …