[HTML][HTML] Landscape of transcription termination in Arabidopsis revealed by single-molecule nascent RNA sequencing
Background The dynamic process of transcription termination produces transient RNA
intermediates that are difficult to distinguish from each other via short-read sequencing …
intermediates that are difficult to distinguish from each other via short-read sequencing …
[HTML][HTML] The 3′ Pol II pausing at replication-dependent histone genes is regulated by Mediator through Cajal bodies' association with histone locus bodies
H Suzuki, R Abe, M Shimada, T Hirose, H Hirose… - Nature …, 2022 - nature.com
Non-polyadenylated mRNAs of replication-dependent histones (RDHs) are synthesized by
RNA polymerase II (Pol II) at histone locus bodies (HLBs). HLBs frequently associate with …
RNA polymerase II (Pol II) at histone locus bodies (HLBs). HLBs frequently associate with …
[HTML][HTML] Coupling of co-transcriptional splicing and 3'end Pol II pausing during termination in Arabidopsis
Abstract Background In Arabidopsis, RNA Polymerase II (Pol II) often pauses within a few
hundred base pairs downstream of the polyadenylation site, reflecting efficient …
hundred base pairs downstream of the polyadenylation site, reflecting efficient …
Structural basis of exoribonuclease-mediated mRNA transcription termination
Y Zeng, HW Zhang, XX Wu, Y Zhang - Nature, 2024 - nature.com
Efficient termination is required for robust gene transcription. Eukaryotic organisms use a
conserved exoribonuclease-mediated mechanism to terminate the mRNA transcription by …
conserved exoribonuclease-mediated mechanism to terminate the mRNA transcription by …
Cytoplasmic binding partners of the Integrator endonuclease INTS11 and its paralog CPSF73 are required for their nuclear function
INTS11 and CPSF73 are metal-dependent endonucleases for Integrator and pre-mRNA 3′-
end processing, respectively. Here, we show that the INTS11 binding partner …
end processing, respectively. Here, we show that the INTS11 binding partner …
[HTML][HTML] Human promoter directionality is determined by transcriptional initiation and the opposing activities of INTS11 and CDK9
JD Eaton, J Board, L Davidson, C Estell, S West - Elife, 2024 - elifesciences.org
Abstract RNA polymerase II (RNAPII) transcription initiates bidirectionally at many human
protein-coding genes. Sense transcription usually dominates and leads to messenger RNA …
protein-coding genes. Sense transcription usually dominates and leads to messenger RNA …
[HTML][HTML] Association with TFIIIC limits MYCN localisation in hubs of active promoters and chromatin accumulation of non-phosphorylated RNA polymerase II
R Vidal, E Leen, S Herold, M Müller, D Fleischhauer… - Elife, 2024 - elifesciences.org
MYC family oncoproteins regulate the expression of a large number of genes and broadly
stimulate elongation by RNA polymerase II (RNAPII). While the factors that control the …
stimulate elongation by RNA polymerase II (RNAPII). While the factors that control the …
Multiple forms and functions of premature termination by RNA polymerase II
DL Bentley - Journal of Molecular Biology, 2024 - Elsevier
Eukaryotic genomes are widely transcribed by RNA polymerase II (pol II) both within genes
and in intergenic regions. POL II elongation complexes comprising the polymerase, the DNA …
and in intergenic regions. POL II elongation complexes comprising the polymerase, the DNA …
ZWC complex-mediated SPT5 phosphorylation suppresses divergent antisense RNA transcription at active gene promoters
K Park, J Zhong, JS Jang, J Kim, HJ Kim… - Nucleic acids …, 2022 - academic.oup.com
The human genome encodes large numbers of non-coding RNAs, including divergent
antisense transcripts at transcription start sites (TSSs). However, molecular mechanisms by …
antisense transcripts at transcription start sites (TSSs). However, molecular mechanisms by …
The TFIIS N-terminal domain (TND): a transcription assembly module at the interface of order and disorder
K Cermakova, V Veverka… - Biochemical Society …, 2023 - portlandpress.com
Interaction scaffolds that selectively recognize disordered protein strongly shape protein
interactomes. An important scaffold of this type that contributes to transcription is the TFIIS N …
interactomes. An important scaffold of this type that contributes to transcription is the TFIIS N …