Mammalian genomes express two principal gene categories through RNA polymerase II-
mediated transcription: protein-coding transcription units and non-coding RNA transcription …

R-loops are non-B DNA structures with intriguing dual consequences for gene expression
and genome stability. In addition to their recognized roles in triggering DNA double-strand …

Eukaryotic gene regulation and pre-mRNA transcription depend on the carboxy-terminal
domain (CTD) of RNA polymerase (Pol) II. Due to its highly repetitive, intrinsically disordered …

Genomic DNA is framed by additional layers of information, referred to as the epigenome.
Epigenomic marks such as DNA methylation, histone modifications, and histone variants are …

The histone chaperone FACT occupies transcribed regions where it plays prominent roles in
maintaining chromatin integrity and preserving epigenetic information. How it is targeted to …

Summary RNA polymerase II (RNA Pol II) contains a disordered C-terminal domain (CTD)
whose length enigmatically correlates with genome size. The CTD is crucial to eukaryotic …

The specific post-translational modifications of the C-terminal domain (CTD) of the Rpb1
subunit of RNA polymerase II (RNAPII) correlate with different stages of transcription. The …

The genomic DNA is constantly under attack by cellular and/or environmental factors.
Fortunately, the cell is armed to safeguard its genome by various mechanisms such as …

Transcriptome‐wide interrogation of eukaryotic genomes has unveiled the pervasive nature
of RNA polymerase II transcription. Virtually, any DNA region with an accessible chromatin …

Most of the world's biodiversity lives in cold (− 2° to 4° C) and hypersaline environments. To
understand how cells adapt to such conditions, we isolated two key components of the …