New directions in therapeutic angiogenesis and arteriogenesis in peripheral arterial disease
The prevalence of peripheral arterial disease (PAD) in the United States exceeds 10 million
people, and PAD is a significant cause of morbidity and mortality across the globe. PAD is …
people, and PAD is a significant cause of morbidity and mortality across the globe. PAD is …
How VEGF-A and its splice variants affect breast cancer development–clinical implications
Background Altered expression levels and structural variations in the vascular endothelial
growth factor (VEGF) have been found to play important roles in cancer development and to …
growth factor (VEGF) have been found to play important roles in cancer development and to …
Systems biology of angiogenesis signaling: Computational models and omics
Angiogenesis is a highly regulated multiscale process that involves a plethora of cells, their
cellular signal transduction, activation, proliferation, differentiation, as well as their …
cellular signal transduction, activation, proliferation, differentiation, as well as their …
VEGF-A splice variants bind VEGFRs with differential affinities
SB Mamer, A Wittenkeller, PI Imoukhuede - Scientific reports, 2020 - nature.com
Vascular endothelial growth factor A (VEGF-A) and its binding to VEGFRs is an important
angiogenesis regulator, especially the earliest-known isoform, VEGF-A165a. Yet several …
angiogenesis regulator, especially the earliest-known isoform, VEGF-A165a. Yet several …
Computer simulation of TSP1 inhibition of VEGF–akt–eNOS: an angiogenesis triple threat
The matricellular protein thrombospondin-1 (TSP1) is a potent inhibitor of angiogenesis.
Specifically, TSP1 has been experimentally shown to inhibit signaling downstream of …
Specifically, TSP1 has been experimentally shown to inhibit signaling downstream of …
Anti-angiogenic isoform of vascular endothelial growth factor-A in cardiovascular and renal disease
R Kikuchi, M Stevens, K Harada, S Oltean… - Advances in clinical …, 2019 - Elsevier
Accumulating evidence suggests that pathologic interactions between the heart and the
kidney can contribute to the progressive dysfunction of both organs. Recently, there has …
kidney can contribute to the progressive dysfunction of both organs. Recently, there has …
Preeclampsia-associated alteration of DNA methylation in fetal endothelial progenitor cells
L Brodowski, T Zindler, S Von Hardenberg… - Frontiers in cell and …, 2019 - frontiersin.org
Objective The pregnancy complication preeclampsia represents an independent risk factor
for cardiovascular disease. Our previous research shows a diminished function of fetal …
for cardiovascular disease. Our previous research shows a diminished function of fetal …
Computational modeling of synergistic interaction between αVβ3 integrin and VEGFR2 in endothelial cells: Implications for the mechanism of action of angiogenesis …
Cooperation between VEGFR2 and integrin αVβ3 is critical for neovascularization in wound
healing, cardiovascular ischemic diseases, ocular diseases, and tumor angiogenesis. In the …
healing, cardiovascular ischemic diseases, ocular diseases, and tumor angiogenesis. In the …
Dynamic multiscale regulation of perfusion recovery in experimental peripheral arterial disease: a mechanistic computational model
In peripheral arterial disease (PAD), the degree of endogenous capacity to modulate
revascularization of limb muscle is central to the management of leg ischemia. To …
revascularization of limb muscle is central to the management of leg ischemia. To …
Computational modeling to quantify the contributions of VEGFR1, VEGFR2, and lateral inhibition in sprouting angiogenesis
C Kühn, S Checa - Frontiers in physiology, 2019 - frontiersin.org
Sprouting angiogenesis is a necessary process in regeneration and development as well as
in tumorigenesis. VEGF-A is the main pro-angiogenic chemoattractant and it can bind to the …
in tumorigenesis. VEGF-A is the main pro-angiogenic chemoattractant and it can bind to the …