Pyroptosis is an inflammatory form of cell death triggered by certain inflammasomes, leading
to the cleavage of gasdermin D (GSDMD) and activation of inactive cytokines like IL-18 and …

More than 600,000 people are diagnosed with esophageal cancer (EC) every year globally,
and the five-year survival rate of EC is less than 20%. Two common histological subtypes of …

Helicobacter pylori (H. pylori) is an extremely common, yet underappreciated, pathogen that
is able to alter host physiology and subvert the host immune response, allowing it to persist …

AIM: To investigate whether there is a link between diabetes mellitus (DM) and
gastroesophageal reflux disease (GERD). METHODS: We conducted a systematic search of …

Reflux esophagitis damages the squamous epithelium that normally lines the esophagus,
and promotes replacement of the damaged squamous lining by the intestinal metaplasia of …

Background & Aims Microbial molecular products incite intestinal inflammation by activating
Toll-like receptors (TLRs) and inflammasomes of the innate immune system. This system's …

Purpose Although risk factors for squamous cell carcinoma of the esophagus and
adenocarcinomas of the esophagus (EA), gastric cardia (GC), and other (noncardia) gastric …

The pathogenesis of subsquamous intestinal metaplasia (SSIM), in which glands of Barrett's
esophagus (BE) are buried under esophageal squamous epithelium, is unknown. In a rat …

Objective To identify and characterise DNA methylation subtypes in oesophageal
adenocarcinoma (EAC) and its precursor Barrett's oesophagus (BE). Design We performed …

Gastroesophageal reflux disease (GERD) clinically predisposes to columnar Barrett's
metaplasia (BM) in the distal esophagus. We demonstrate evidence supporting the cellular …