Epidemiological studies have shown that women who use third‐generation oral
contraceptives (OC) containing desogestrel, gestodene or norgestimate have a higher risk of …

Background The factor Va molecule is generated by cleavage of its precursor factor V. It
contributes to the blood clotting reaction by binding with factor Xa on a membrane surface to …

The generation of thrombin by the prothrombinase complex constitutes an essential step in
hemostasis, with thrombin being crucial for the amplification of blood coagulation, fibrin …

Since publication of the First Edition in 1982, Hemostasis and Thrombosis has established
itself as the pre-eminent book in the field of coagulation disorders. No other book is as …

BACKGROUND AND OBJECTIVE: Venous thrombosis is a common disease annually
affecting 1 in 1000 individuals. The multifactorial nature of the disease is illustrated by the …

Human coagulation factor V (FV) is an essential coagulation protein with functions in both
the pro-and anticoagulant pathways. Failure to express and control FV functions can either …

Blood coagulation can be initiated by two pathways: the extrinsic pathway, which is triggered
by release of tissue factor from the site of injury, and the intrinsic system, which is stimulated …

Protein S is a critical regulator of coagulation that functions as a cofactor for the activated
protein C (APC) and tissue factor pathway inhibitor (TFPI) pathways. It also has direct …

Inactivation of membrane-bound factor Va by activated protein C (APC) proceeds via a
biphasic reaction that consists of a rapid and a slow phase, which are associated with …

Thrombophilia can be identified in about half of all patients presenting with venous
thrombosis. Testing has increased tremendously for various indications, but whether the …