Impaired APC cofactor activity of factor V plays a major role in the APC resistance associated with the factor V Leiden (R506Q) and R2 (H1299R) mutations
E Castoldi, JM Brugge, GAF Nicolaes, D Girelli, G Tans… - Blood, 2004 - ashpublications.org
Activated protein C (APC) resistance is a major risk factor for venous thrombosis. Factor V
(FV) gene mutations like FVLeiden (R506Q) and FVR2 (H1299R) may cause APC …
(FV) gene mutations like FVLeiden (R506Q) and FVR2 (H1299R) may cause APC …
Design and characterization of novel activated protein C variants for the proteolysis of cytotoxic extracellular histone H3
JB Huckriede, DMH Beurskens… - Journal of Thrombosis …, 2023 - Elsevier
Background Extracellular histone H3 is implicated in several pathologies including
inflammation, cell death, and organ failure. Neutralization of histone H3 is a strategy that …
inflammation, cell death, and organ failure. Neutralization of histone H3 is a strategy that …
[HTML][HTML] Anti‐protein C antibodies are associated with resistance to endogenous protein C activation and a severe thrombotic phenotype in antiphospholipid …
DRJ Arachchillage, M Efthymiou, IJ Mackie… - Journal of Thrombosis …, 2014 - Elsevier
Background Antiphospholipid antibodies may interfere with the anticoagulant activity of
activated protein C (APC) to induce acquired APC resistance (APCr). Aims To investigate …
activated protein C (APC) to induce acquired APC resistance (APCr). Aims To investigate …
[HTML][HTML] Factor V Leiden-independent activated protein C resistance: communication from the plasma coagulation inhibitors subcommittee of the International Society …
GW Moore, E Castoldi, J Teruya, E Morishita… - Journal of Thrombosis …, 2023 - Elsevier
Activated protein C resistance (APC-R) due to the single-nucleotide polymorphism factor V
Leiden (FVL) is the most common cause of hereditary thrombophilia. It is found …
Leiden (FVL) is the most common cause of hereditary thrombophilia. It is found …
Advances in understanding the bleeding diathesis in factor V deficiency
C Duckers, P Simioni, J Rosing… - British journal of …, 2009 - Wiley Online Library
Coagulation factor V (FV), present in plasma and platelets, is an indispensable clotting
factor, as demonstrated by the uniform lethality of FV knock‐out mice. Surprisingly, however …
factor, as demonstrated by the uniform lethality of FV knock‐out mice. Surprisingly, however …
HIV replication alters the composition of extrinsic pathway coagulation factors and increases thrombin generation
JV Baker, K Brummel‐Ziedins, J Neuhaus… - Journal of the …, 2013 - Am Heart Assoc
Background HIV infection leads to activation of coagulation, which may increase the risk for
atherosclerosis and venous thromboembolic disease. We hypothesized that HIV replication …
atherosclerosis and venous thromboembolic disease. We hypothesized that HIV replication …
Novel FV mutation (W1920R, FVNara) associated with serious deep vein thrombosis and more potent APC resistance relative to FVLeiden
K Nogami, K Shinozawa, K Ogiwara… - Blood, The Journal …, 2014 - ashpublications.org
Factor V (FV) appears to be pivotal in both procoagulant and anticoagulant mechanisms. A
novel homozygote (FVNara), a novel mechanism of thrombosis associated with Trp1920→ …
novel homozygote (FVNara), a novel mechanism of thrombosis associated with Trp1920→ …
[HTML][HTML] Molecular recognition in the protein C anticoagulant pathway
B Dahlbäck, BO Villoutreix - Journal of thrombosis and haemostasis, 2003 - Elsevier
The protein C (PC) anticoagulant system provides specific and efficient control of blood
coagulation. The system comprises circulating or membrane-bound protein components that …
coagulation. The system comprises circulating or membrane-bound protein components that …
[HTML][HTML] Determinants of the APTT‐and ETP‐based APC sensitivity tests
MCH De Visser, AVH Vlieg, G Tans, J Rosing… - Journal of Thrombosis …, 2005 - Elsevier
Background: A reduced sensitivity for activated protein C (APC) is associated with an
increased risk of venous thrombosis even in the absence of the factor (F) V Leiden mutation …
increased risk of venous thrombosis even in the absence of the factor (F) V Leiden mutation …
Effect of activated protein C on thrombin generation and on the thrombin potential in plasma of normal and APC-resistant individuals
GAF Nicolaes, M Thomassen, G Tans… - Blood coagulation & …, 1997 - journals.lww.com
In this paper we describe the effect of activated protein C (APC) on thrombin generation
initiated in platelet-poor plasma via the extrinsic or the intrinsic pathway. Thrombin was …
initiated in platelet-poor plasma via the extrinsic or the intrinsic pathway. Thrombin was …