The location of the active site of membrane-bound activated protein C (APC) relative to the
phospholipid surface was determined both in the presence and absence of its cofactor …

Already in 1908, Nolf (1) posrulated the existence of a plasma component which was later
identified as factor V (2), also called accelerator globulin (Ac-globulin)(3) or proaccelerin …

TM modulates the activity of thrombin. It inhibits its procoagulant properties and seryes as a
cofactor to thrombin in the activation of protein C. Activated protein C (APC) regulates the …

Factor X is the rymogen of factor Xa, a serine protease which occupies a pivotal position in
the clotting process. It is activated either by the contact-activated (intrinsic) pathway or by the …

Almost two decades ago an anticoagulant function of factor V (FV) was discovered, as an
anticoagulant cofactor for activated protein C (APC). A natural mutant of FV in which the …

We studied the HR2 haplotype of the factor V gene in a case-control study for venous
thrombosis including 474 patients with a first deep-vein thrombosis and 474 age-and sex …

Activated protein C (APC) is a plasma serine protease with antithrombotic and cytoprotective
functions. Based on the hypothesis that specific inhibition of APC's anticoagulant but not its …

A soluble form of the endothelial cell protein C receptor (EPCR) was analyzed for the ability
to modulate the functional properties of protein C and activated protein C (APC). In a plasma …

[Frontiers in Bioscience 11, 2381-2399, September 1, 2006] 2381 Protein C anticoagulant
activity in relation to anti-inflammator Page 1 [Frontiers in Bioscience 11, 2381-2399, September …

Venous thrombosis is a multifactorial disease, with the pathogenesis involving genetic and
environmental risk factors. The most common genetic risk factor known to date is a single …