Introduction Severe congenital factor V (FV) deficiency is a rare bleeding disorder
characterized by very low/undetectable levels of FV. Fresh frozen plasma is the standard …

Activated coagulation factor V (FVa) functions as a cofactor to factor Xa (FXa) in the
conversion of prothrombin (PT) to thrombin. This essential procoagulant reaction, despite …

Background Activated factor V (FVa) is a potent procoagulant cofactor in the prothrombinase
complex, whereas its precursor factor V (FV) stimulates the inhibition of factor Xa (FXa) by …

Vitamin K is required for the synthesis of γ-carboxyglutamate (Gla) during postribosomal
protein modification. Substrates include blood clotting proteins, vone proteins, cell signaling …

Abstract Background Activated protein C (APC)‐mediated inactivation of factor (F) Va is
greatly enhanced by protein S. For inactivation to occur, a trimolecular complex among FVa …

Factor VIIIa is inactivated by a combination of two mechanisms. Activation of factor VIII by
thrombin results in a heterotrimeric factor VIIIa that spontaneously inactivates due to …

Background: Protein S is a central regulator of coagulation as it critically participates in down-
regulation of both extrinsic and intrinsic pathways of the coagulation cascade. In this review …

Protein C is the central enzyme of the natural anticoagulant pathway and its activated form
APC (activated protein C) is able to proteolyse non-active as well as active coagulation …

Coagulation factor V (FV) circulates in two forms, FV1 and FV2, having slightly different
molecular masses and phospholipid-binding properties. The aim was to determine whether …

The APC-cofactor activity of FV and its impairment in FV Leiden can explain the different
thrombosis risks associated with heterozygosity, homozygosity and pseudo-homozygosity …