Type 2 diabetes mellitus in older adults: clinical considerations and management
S Bellary, I Kyrou, JE Brown, CJ Bailey - Nature Reviews Endocrinology, 2021 - nature.com
The past 50 years have seen a growing ageing population with an increasing prevalence of
type 2 diabetes mellitus (T2DM); now, nearly half of all individuals with diabetes mellitus are …
type 2 diabetes mellitus (T2DM); now, nearly half of all individuals with diabetes mellitus are …
Comparing clinical trial population representativeness to real-world populations: an external validity analysis encompassing 43 895 trials and 5 685 738 individuals …
YY Tan, V Papez, WH Chang, SH Mueller… - The Lancet Healthy …, 2022 - thelancet.com
Summary Background Randomised controlled trials (RCTs) inform prescription guidelines,
but stringent eligibility criteria exclude individuals with vulnerable characteristics, which we …
but stringent eligibility criteria exclude individuals with vulnerable characteristics, which we …
Examining variation in the measurement of multimorbidity in research: a systematic review of 566 studies
Background A systematic understanding of how multimorbidity has been constructed and
measured is unavailable. This review aimed to examine the definition and measurement of …
measured is unavailable. This review aimed to examine the definition and measurement of …
Optimizing therapy to prevent avoidable hospital admissions in multimorbid older adults (OPERAM): cluster randomised controlled trial
MR Blum, BTGM Sallevelt, A Spinewine, D O'Mahony… - bmj, 2021 - bmj.com
Objective To examine the effect of optimising drug treatment on drug related hospital
admissions in older adults with multimorbidity and polypharmacy admitted to hospital …
admissions in older adults with multimorbidity and polypharmacy admitted to hospital …
Impact of multimorbidity on healthcare costs and utilisation: a systematic review of the UK literature
Background Managing multimorbidity is complex for both patients and healthcare systems.
Patients with multimorbidity often use a variety of primary and secondary care services …
Patients with multimorbidity often use a variety of primary and secondary care services …
Association between multimorbidity and hospitalization in older adults: systematic review and meta-analysis
LP Rodrigues, AT de Oliveira Rezende… - Age and …, 2022 - academic.oup.com
Background Multimorbidity is defined as the presence of multiple chronic conditions in the
same individual. Multimorbidity is more prevalent in older adults and can lead to several …
same individual. Multimorbidity is more prevalent in older adults and can lead to several …
Inequalities in incident and prevalent multimorbidity in England, 2004–19: a population-based, descriptive study
A Head, K Fleming, C Kypridemos… - The Lancet Healthy …, 2021 - thelancet.com
Background The increasing burden of multimorbidity and its socioeconomic gradient poses
unique challenges to the provision and structure of health care. We aimed to describe …
unique challenges to the provision and structure of health care. We aimed to describe …
[HTML][HTML] LSE–Lancet Commission on the future of the NHS: re-laying the foundations for an equitable and efficient health and care service after COVID-19
The UK has recorded one of the highest death rates associated with COVID-19 globally,
whether measured as deaths that are directly attributable to COVID-19 or by excess …
whether measured as deaths that are directly attributable to COVID-19 or by excess …
[HTML][HTML] Drug related problems in clinical practice: a cross-sectional study on their prevalence, risk factors and associated pharmaceutical interventions
N Garin, N Sole, B Lucas, L Matas, D Moras… - Scientific reports, 2021 - nature.com
Drug-related problems (DRP) cause preventable negative health outcomes, especially
during hospital admissions. The aim of our study was to examine the prevalence and …
during hospital admissions. The aim of our study was to examine the prevalence and …