Therapeutic drug monitoring (TDM) is the quantification and interpretation of drug
concentrations in blood to optimize pharmacotherapy. It considers the interindividual …

Objective To compare the risk for all cause and overdose mortality in people with opioid
dependence during and after substitution treatment with methadone or buprenorphine and …

Therapeutic drug monitoring (TDM), ie, the quantification of serum or plasma concentrations
of medications for dose optimization, has proven a valuable tool for the patient-matched …

These Guidelinesreview the use of medicines such as methadone, buprenorphine,
naltrexone and clonidine in combination with psychosocial support in the treatment of …

Moderate to severe pain occurs in many cancer patients during their clinical course and may
stem from the primary pathology, metastasis, or as treatment side effects. Uncontrolled pain …

Objective. A panel of experts in pain medicine and public policy convened to examine root
causes and risk factors for opioid-related poisoning deaths and to propose …

Abstract The United States is in the midst of a national opioid epidemic. Physicians are
encouraged both to prevent and treat opioid-use disorders (OUDs). Although there are 3 …

Methadone is used for the treatment of opioid addiction and for treatment of chronic pain.
The safety of methadone has been called into question by data indicating a large increase in …

Aims To determine the acute lethal toxicity of a range of psychoactive substances in terms of
the dose customarily used as a single substance for non‐medical purposes. Design and …

Therapeutic Drug Monitoring (TDM) is a valid tool to optimise pharmacotherapy. It enables
the clinician to adjust the dosage of drugs according to the characteristics of the individual …