Emerging targets in type 2 diabetes and diabetic complications
S Demir, PP Nawroth, S Herzig… - Advanced …, 2021 - Wiley Online Library
Type 2 diabetes is a metabolic, chronic disorder characterized by insulin resistance and
elevated blood glucose levels. Although a large drug portfolio exists to keep the blood …
elevated blood glucose levels. Although a large drug portfolio exists to keep the blood …
[HTML][HTML] The hexosamine biosynthesis pathway: regulation and function
A Paneque, H Fortus, J Zheng, G Werlen, E Jacinto - Genes, 2023 - mdpi.com
The hexosamine biosynthesis pathway (HBP) produces uridine diphosphate-N-acetyl
glucosamine, UDP-GlcNAc, which is a key metabolite that is used for N-or O-linked …
glucosamine, UDP-GlcNAc, which is a key metabolite that is used for N-or O-linked …
The regulation of PKA signaling in obesity and in the maintenance of metabolic health
E London, CA Stratakis - Pharmacology & therapeutics, 2022 - Elsevier
The cAMP-dependent protein kinase (PKA) system represents a primary cell-signaling
pathway throughout systems and across species. PKA facilitates the actions of hormones …
pathway throughout systems and across species. PKA facilitates the actions of hormones …
[HTML][HTML] Phosphorylation of 17β-hydroxysteroid dehydrogenase 13 at serine 33 attenuates nonalcoholic fatty liver disease in mice
Abstract 17β-hydroxysteroid dehydrogenase-13 is a hepatocyte-specific, lipid droplet-
associated protein. A common loss-of-function variant of HSD17B13 (rs72613567: TA) …
associated protein. A common loss-of-function variant of HSD17B13 (rs72613567: TA) …
Dendrobium officinale polysaccharide ameliorates diabetic hepatic glucose metabolism via glucagon-mediated signaling pathways and modifying liver-glycogen …
Y Liu, L Yang, Y Zhang, X Liu, Z Wu, RG Gilbert… - Journal of …, 2020 - Elsevier
Ethnopharmacological relevance Dendrobium officinale polysaccharide (DOP) is the main
active ingredient of Dendrobium officinale Kimura & Migo, which is a precious traditional …
active ingredient of Dendrobium officinale Kimura & Migo, which is a precious traditional …
[HTML][HTML] The pathogenesis of diabetes
H Guo, H Wu, Z Li - International journal of molecular sciences, 2023 - mdpi.com
Diabetes is the most common metabolic disorder, with an extremely serious effect on health
systems worldwide. It has become a severe, chronic, non-communicable disease after …
systems worldwide. It has become a severe, chronic, non-communicable disease after …
Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes
We have identified a variant in ADCY3 (encoding adenylate cyclase 3) associated with
markedly increased risk of obesity and type 2 diabetes in the Greenlandic population. The …
markedly increased risk of obesity and type 2 diabetes in the Greenlandic population. The …
Gαs–Protein kinase a (PKA) pathway signalopathies: the emerging genetic landscape and therapeutic potential of human diseases driven by aberrant Gαs-PKA …
Many of the fundamental concepts of signal transduction and kinase activity are attributed to
the discovery and crystallization of cAMP-dependent protein kinase, or protein kinase A …
the discovery and crystallization of cAMP-dependent protein kinase, or protein kinase A …
[HTML][HTML] Single-cell RNA profiling reveals adipocyte to macrophage signaling sufficient to enhance thermogenesis
Adipocytes deficient in fatty acid synthase (iAdFASNKO) emit signals that mimic cold
exposure to enhance the appearance of thermogenic beige adipocytes in mouse inguinal …
exposure to enhance the appearance of thermogenic beige adipocytes in mouse inguinal …
[HTML][HTML] Pro-inflammatory β cell small extracellular vesicles induce β cell failure through activation of the CXCL10/CXCR3 axis in diabetes
Coordinated communication among pancreatic islet cells is necessary for maintenance of
glucose homeostasis. In diabetes, chronic exposure to pro-inflammatory cytokines has been …
glucose homeostasis. In diabetes, chronic exposure to pro-inflammatory cytokines has been …