Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of …

BV Zlokovic, RF Gottesman, KE Bernstein… - Alzheimer's & …, 2020 - Wiley Online Library
Vascular contributions to cognitive impairment and dementia (VCID) are characterized by
the aging neurovascular unit being confronted with and failing to cope with biological insults …

A major role for cardiovascular burden in age-related cognitive decline

C Qiu, L Fratiglioni - Nature Reviews Cardiology, 2015 - nature.com
The incidence of dementia and cardiovascular disease (CVD) increases with age. Current
evidence supports the role for both atherosclerosis and arteriosclerosis as a common …

Type 2 diabetes as a risk factor for cognitive impairment: current insights

H Umegaki - Clinical interventions in aging, 2014 - Taylor & Francis
Type 2 diabetes mellitus (T2DM) is a risk factor for cognitive dysfunction and dementia in the
elderly. T2DM has been thought to be associated with vascular diseases, eventually leading …

Chronic kidney disease and neurological disorders: are uraemic toxins the missing piece of the puzzle?

S Liabeuf, M Pepin, CFM Franssen… - Nephrology Dialysis …, 2022 - academic.oup.com
Chronic kidney disease (CKD) perturbs the crosstalk with others organs, with the interaction
between the kidneys and the heart having been studied most intensively. However, a …

Brain health and shared risk factors for dementia and stroke

H Gardener, CB Wright, T Rundek… - Nature Reviews …, 2015 - nature.com
Impaired brain health encompasses a range of clinical outcomes, including stroke,
dementia, vascular cognitive impairment, cognitive ageing, and vascular functional …

Brain functional magnetic resonance imaging highlights altered connections and functional networks in patients with hypertension

L Carnevale, A Maffei, A Landolfi, G Grillea… - …, 2020 - Am Heart Assoc
Hypertension is one of the main risk factors for vascular dementia and Alzheimer disease.
To predict the onset of these diseases, it is necessary to develop tools to detect the early …

Atrial fibrillation and cognitive decline in the Framingham Heart Study

A Nishtala, RJ Piers, JJ Himali, AS Beiser… - Heart rhythm, 2018 - Elsevier
Background There is a paucity of longitudinal research investigating the relations between
atrial fibrillation (AF) and domain-specific cognitive performance. Objective The purpose of …

Ideal cardiovascular health and cognitive aging in the Northern Manhattan Study

H Gardener, CB Wright, C Dong, K Cheung… - Journal of the …, 2016 - Am Heart Assoc
Background The American Heart Association defined target levels for 7 cardiovascular
health (CVH) factors: smoking, body mass index, physical activity, diet, blood pressure …

Hearts and minds: linking vascular rigidity and aerobic fitness with cognitive aging

CJ Gauthier, M Lefort, S Mekary… - Neurobiology of …, 2015 - Elsevier
Human aging is accompanied by both vascular and cognitive changes. Although arteries
throughout the body are known to become stiffer with age, this vessel hardening is believed …

Associations between cardiorespiratory fitness, cardiovascular risk, and cognition are mediated by structural brain health in midlife

G España‐Irla, J Gomes‐Osman… - Journal of the …, 2021 - Am Heart Assoc
Background Evidence in older adults suggests that higher cardiorespiratory fitness and
lower cardiovascular risk are associated with greater cognition. However, given that …