The multi-factorial nature of clinical multidrug resistance in cancer
Curative cancer therapy remains a major challenge particularly in cancers displaying
multidrug resistance (MDR). The MDR phenotype is characterized by cross-resistance to a …
multidrug resistance (MDR). The MDR phenotype is characterized by cross-resistance to a …
DNA methyltransferases in cancer: biology, paradox, aberrations, and targeted therapy
J Zhang, C Yang, C Wu, W Cui, L Wang - Cancers, 2020 - mdpi.com
DNA methyltransferases are an essential class of modifiers in epigenetics. In mammals,
DNMT1, DNMT3A and DNMT3B participate in DNA methylation to regulate normal …
DNMT1, DNMT3A and DNMT3B participate in DNA methylation to regulate normal …
Mapping epigenetic modifications by sequencing technologies
The “epigenetics” concept was first described in 1942. Thus far, chemical modifications on
histones, DNA, and RNA have emerged as three important building blocks of epigenetic …
histones, DNA, and RNA have emerged as three important building blocks of epigenetic …
HDAC inhibitors in acute myeloid leukemia
E San José-Enériz, N Gimenez-Camino, X Agirre… - Cancers, 2019 - mdpi.com
Acute myeloid leukemia (AML) is a hematological malignancy characterized by uncontrolled
proliferation, differentiation arrest, and accumulation of immature myeloid progenitors …
proliferation, differentiation arrest, and accumulation of immature myeloid progenitors …
CD8+ T cell exhaustion and cancer immunotherapy
Q Wang, Y Qin, B Li - Cancer letters, 2023 - Elsevier
Immunotherapy plays an increasingly important role in the treatment of most malignant
tumors, and CD8+ T cells are the most important antitumor effector cells in the process of …
tumors, and CD8+ T cells are the most important antitumor effector cells in the process of …
[HTML][HTML] The crosstalk between m6A RNA methylation and other epigenetic regulators: a novel perspective in epigenetic remodeling
Y Zhao, Y Chen, M Jin, J Wang - Theranostics, 2021 - ncbi.nlm.nih.gov
Epigenetic regulation involves a range of sophisticated processes which contribute to
heritable alterations in gene expression without altering DNA sequence. Regulatory events …
heritable alterations in gene expression without altering DNA sequence. Regulatory events …
Ovarian cancer: epigenetics, drug resistance, and progression
W Xie, H Sun, X Li, F Lin, Z Wang, X Wang - Cancer cell international, 2021 - Springer
Ovarian cancer (OC) is one of the most common malignant tumors in women. OC is
associated with the activation of oncogenes, the inactivation of tumor suppressor genes, and …
associated with the activation of oncogenes, the inactivation of tumor suppressor genes, and …
Combining histone deacetylase inhibitors (HDACis) with other therapies for cancer therapy
Histone deacetylases (HDACs) play an important role in regulating the expression of genes
involved in tumorigenesis and tumor maintenance, and hence they have been considered …
involved in tumorigenesis and tumor maintenance, and hence they have been considered …
Drug resistance mechanisms of acute myeloid leukemia stem cells
J Niu, D Peng, L Liu - Frontiers in Oncology, 2022 - frontiersin.org
Acute myeloid leukemia (AML) is a polyclonal and heterogeneous hematological
malignancy. Relapse and refractory after induction chemotherapy are still challenges for …
malignancy. Relapse and refractory after induction chemotherapy are still challenges for …
Dual inhibitors of histone deacetylases and other cancer-related targets: A pharmacological perspective
Epigenetic enzymes histone deacetylases (HDACs) are clinically validated anticancer drug
targets which have been studied intensively in the past few decades. Although several drugs …
targets which have been studied intensively in the past few decades. Although several drugs …