RNA in cancer

GJ Goodall, VO Wickramasinghe - Nature Reviews Cancer, 2021 - nature.com
While the processing of mRNA is essential for gene expression, recent findings have
highlighted that RNA processing is systematically altered in cancer. Mutations in RNA …

[HTML][HTML] Osteoarthritis: pathogenic signaling pathways and therapeutic targets

Q Yao, X Wu, C Tao, W Gong, M Chen, M Qu… - … and Targeted Therapy, 2023 - nature.com
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …

Insight into polyphenol and gut microbiota crosstalk: are their metabolites the key to understand protective effects against metabolic disorders?

M Koudoufio, Y Desjardins, F Feldman, S Spahis… - Antioxidants, 2020 - mdpi.com
Lifestyle factors, especially diet and nutrition, are currently regarded as essential avenues to
decrease modern-day cardiometabolic disorders (CMD), including obesity, metabolic …

MicroRNAs involved in carcinogenesis, prognosis, therapeutic resistance, and applications in human triple-negative breast cancer

L Ding, H Gu, X Xiong, H Ao, J Cao, W Lin, M Yu, J Lin… - Cells, 2019 - mdpi.com
Triple-negative breast cancer (TNBC) is the most aggressive, prevalent, and distinct subtype
of breast cancer characterized by high recurrence rates and poor clinical prognosis, devoid …

[HTML][HTML] Epigenetic biomarkers in cardiovascular diseases

C Soler-Botija, C Gálvez-Montón… - Frontiers in genetics, 2019 - frontiersin.org
Cardiovascular diseases are the number one cause of death worldwide and greatly impact
quality of life and medical costs. Enormous effort has been made in research to obtain new …

Genetic and epigenetic alterations induced by pesticide exposure: integrated analysis of gene expression, microRNA expression, and DNA methylation datasets

F Giambò, GM Leone, G Gattuso, R Rizzo… - International journal of …, 2021 - mdpi.com
Environmental or occupational exposure to pesticides is considered one of the main risk
factors for the development of various diseases. Behind the development of pesticide …

The key roles of the lysine acetyltransferases KAT6A and KAT6B in physiology and pathology

N Wiesel-Motiuk, YG Assaraf - Drug Resistance Updates, 2020 - Elsevier
Histone modifications and more specifically ε-lysine acylations are key epigenetic regulators
that control chromatin structure and gene transcription, thereby impacting on various …

[HTML][HTML] MicroRNAs in blood and cerebrospinal fluid as diagnostic biomarkers of multiple sclerosis and to monitor disease progression

B Martinez, PV Peplow - Neural regeneration research, 2020 - ncbi.nlm.nih.gov
Multiple sclerosis is a chronic autoimmune disease of the central nervous system. It is the
main cause of non-traumatic neurological disability in young adults. Multiple sclerosis mostly …

Epigenetic variation in animal populations: Sources, extent, phenotypic implications, and ecological and evolutionary relevance

G Vogt - Journal of Biosciences, 2021 - Springer
Laboratory experiments and fieldwork with asexually reproducing invertebrates and
vertebrates clearly revealed that animal populations can produce substantial phenotypic …

p53 at the crossroads between different types of HDAC inhibitor-mediated cancer cell death

M Mrakovcic, J Kleinheinz, LF Fröhlich - International journal of molecular …, 2019 - mdpi.com
Cancer is a complex genetic and epigenetic-based disease that has developed an armada
of mechanisms to escape cell death. The deregulation of apoptosis and autophagy, which …