RNA in cancer
GJ Goodall, VO Wickramasinghe - Nature Reviews Cancer, 2021 - nature.com
While the processing of mRNA is essential for gene expression, recent findings have
highlighted that RNA processing is systematically altered in cancer. Mutations in RNA …
highlighted that RNA processing is systematically altered in cancer. Mutations in RNA …
[HTML][HTML] Osteoarthritis: pathogenic signaling pathways and therapeutic targets
Q Yao, X Wu, C Tao, W Gong, M Chen, M Qu… - … and Targeted Therapy, 2023 - nature.com
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …
more than 500 million population worldwide. OA was believed to be caused by the wearing …
Insight into polyphenol and gut microbiota crosstalk: are their metabolites the key to understand protective effects against metabolic disorders?
M Koudoufio, Y Desjardins, F Feldman, S Spahis… - Antioxidants, 2020 - mdpi.com
Lifestyle factors, especially diet and nutrition, are currently regarded as essential avenues to
decrease modern-day cardiometabolic disorders (CMD), including obesity, metabolic …
decrease modern-day cardiometabolic disorders (CMD), including obesity, metabolic …
MicroRNAs involved in carcinogenesis, prognosis, therapeutic resistance, and applications in human triple-negative breast cancer
L Ding, H Gu, X Xiong, H Ao, J Cao, W Lin, M Yu, J Lin… - Cells, 2019 - mdpi.com
Triple-negative breast cancer (TNBC) is the most aggressive, prevalent, and distinct subtype
of breast cancer characterized by high recurrence rates and poor clinical prognosis, devoid …
of breast cancer characterized by high recurrence rates and poor clinical prognosis, devoid …
[HTML][HTML] Epigenetic biomarkers in cardiovascular diseases
C Soler-Botija, C Gálvez-Montón… - Frontiers in genetics, 2019 - frontiersin.org
Cardiovascular diseases are the number one cause of death worldwide and greatly impact
quality of life and medical costs. Enormous effort has been made in research to obtain new …
quality of life and medical costs. Enormous effort has been made in research to obtain new …
Genetic and epigenetic alterations induced by pesticide exposure: integrated analysis of gene expression, microRNA expression, and DNA methylation datasets
Environmental or occupational exposure to pesticides is considered one of the main risk
factors for the development of various diseases. Behind the development of pesticide …
factors for the development of various diseases. Behind the development of pesticide …
The key roles of the lysine acetyltransferases KAT6A and KAT6B in physiology and pathology
N Wiesel-Motiuk, YG Assaraf - Drug Resistance Updates, 2020 - Elsevier
Histone modifications and more specifically ε-lysine acylations are key epigenetic regulators
that control chromatin structure and gene transcription, thereby impacting on various …
that control chromatin structure and gene transcription, thereby impacting on various …
[HTML][HTML] MicroRNAs in blood and cerebrospinal fluid as diagnostic biomarkers of multiple sclerosis and to monitor disease progression
B Martinez, PV Peplow - Neural regeneration research, 2020 - ncbi.nlm.nih.gov
Multiple sclerosis is a chronic autoimmune disease of the central nervous system. It is the
main cause of non-traumatic neurological disability in young adults. Multiple sclerosis mostly …
main cause of non-traumatic neurological disability in young adults. Multiple sclerosis mostly …
Epigenetic variation in animal populations: Sources, extent, phenotypic implications, and ecological and evolutionary relevance
G Vogt - Journal of Biosciences, 2021 - Springer
Laboratory experiments and fieldwork with asexually reproducing invertebrates and
vertebrates clearly revealed that animal populations can produce substantial phenotypic …
vertebrates clearly revealed that animal populations can produce substantial phenotypic …
p53 at the crossroads between different types of HDAC inhibitor-mediated cancer cell death
M Mrakovcic, J Kleinheinz, LF Fröhlich - International journal of molecular …, 2019 - mdpi.com
Cancer is a complex genetic and epigenetic-based disease that has developed an armada
of mechanisms to escape cell death. The deregulation of apoptosis and autophagy, which …
of mechanisms to escape cell death. The deregulation of apoptosis and autophagy, which …