Background: Aberrant activation of the phosphatidylinositol-3 kinase (PI3K)/Akt pathway
plays a fundamental role in thyroid tumorigenesis, particularly in follicular thyroid cancer …

Aberrant activation of Wnt signaling is involved in the development of several epithelial
tumors. Wnt signaling includes two major types of pathways:(i) the canonical or Wnt/β …

Objective Papillary thyroid carcinoma (PTC) represents the majority of differentiated thyroid
cancers, presenting the V600E activating BRAF mutation in 29–83% of cases. The aim of …

Mutations in ß-catenin are traditionally described as late events in thyroid cancer
progression. However, the functional implications of ß-catenin dysregulation in the context of …

The role of long non-coding RNA (lncRNA) HOX transcript antisense RNA (HOTAIR) in
thyroid carcinoma (TC) remains unclear. The current study was aimed to assess the clinical …

Purpose: This study was designed to explore the role of IQGAP1 in the invasiveness of
thyroid cancer and its potential as a novel prognostic marker and therapeutic target in this …

The accurate preoperative diagnosis of thyroid cancer continues to be a significant
challenge for those individuals who present with nodular thyroid disease, particularly for …

The association between thyroid cancer and thyroid inflammation has been repeatedly
reported and highly debated in the literature. In fact, both molecular and epidemiological …

The aim of this study is to assess if common genetic variants located in the CDKN1B locus,
coding for the cell cycle inhibitor p27 Kip1, are involved in thyroid cancer susceptibility …

Background Survival rate of patients affected with anaplastic thyroid carcinoma (ATC) is less
than 5% with current treatment. In ATC, BRAF V600E mutation is the major mutation that …