The DNA damage response (DDR) is essential for maintaining the genomic integrity of the
cell, and its disruption is one of the hallmarks of cancer. Classically, defects in the DDR have …

Genomic instability can initiate cancer, augment progression, and influence the overall
prognosis of the affected patient. Genomic instability arises from many different pathways …

INTRODUCTION Genetic interactions occur when mutations in two or more genes combine
to generate an unexpected phenotype. An extreme negative or synthetic lethal genetic …

The principle of synthetic lethality, which refers to the loss of viability resulting from the
disruption of two genes, which, individually, do not cause lethality, has become an attractive …

Worldwide breast cancer is the most common cancer in women. For many years clinicians
and the researchers are examining and exploring various therapeutic modalities for breast …

Disruptions in DNA repair pathways predispose cells to accumulating DNA damage. A
growing body of evidence indicates that tumors accumulate progressively more mutations in …

Base excision repair (BER) has evolved to preserve the integrity of DNA following cellular
oxidative stress and in response to exogenous insults. The pathway is a coordinated …

An emerging therapeutic strategy for cancer is to induce selective lethality in a tumor by
exploiting interactions between its driving mutations and specific drug targets. Here we use …

DNA replication and repair enzyme Flap Endonuclease 1 (FEN1) is vital for genome
integrity, and FEN1 mutations arise in multiple cancers. FEN1 precisely cleaves single …

Abstract DNA flap endonuclease 1 (FEN1) plays critical roles in maintaining genome
stability and integrity by participating in both DNA replication and repair. Suppression of …