Background: Bone is a frequent site of metastases from breast cancer, but existing
therapeutic options are not satisfactory. Although osteoblasts have active roles in cancer …

Abstract Purpose of Review The purpose of this review was to describe the characteristics of
breast cancer cells prone to developing bone metastasis and determine how they are …

Unlike a prevalent expectation that tumor cells secrete tumor-promoting proteins and
stimulate the progression of neighboring tumor cells, accumulating evidence indicates that …

Background: Advanced breast cancer frequently metastasizes to bone, but inhibiting tumor
progression in chemotherapy may occasionally enhance tumorigenesis. Here, we employed …

Osteosarcoma (OS) is the common primary bone cancer that affects mostly children and
young adults. To augment the standard-of-care chemotherapy, we examined the possibility …

Background: During a developmental process, embryos employ varying tactics to remove
unwanted cells. Using a procedure analogous to some of the embryonic cells, we generated …

Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is a tough cancer. Instead of
stopping certain genes, we used their power to change tumors. Surprisingly, some proteins …

PDAC (pancreatic ductal adenocarcinoma) is a highly aggressive malignant tumor. We have
previously developed induced tumor-suppressing cells (iTSCs) that secrete a group of tumor …

Despite the advance in medications in the past decade, aggressive breast cancer such as
triple-negative breast cancer is difficult to treat. Here, we examined a counter-intuitive …

Cisplatin resistance is a crucial factor affecting ovarian cancer patient's survival rate, but the
primary mechanism underlying cisplatin resistance in ovarian cancer remains unclear, and …