Endothelial cells (ECs) lining all blood vessels are subjected to large mechanical stresses
that regulate their structure and function in health and disease. Here, we review EC …

The cornea, as a dynamic and responsive tissue, constantly interacts with mechanical forces
in order to maintain its structural integrity, barrier function, transparency and refractive …

Blood-vessel formation generates unique vascular patterns in each individual. The
principles governing the apparent stochasticity of this process remain to be elucidated …

Background Lung adenocarcinoma (LUAD) remains a global health concern with its poor
prognosis and high mortality. Whether tumor cells invade through the basement membrane …

Inflammatory diseases are often characterised by excessive neutrophil infiltration from the
blood stream to the site of inflammation, which damages healthy tissue and prevents …

Pericytes are mural cells of the microvasculature, recognized by their thin processes and
protruding cell body. Pericytes wrap around endothelial cells and play a central role in …

Pulmonary hypertension (PH) is a condition characterized by changes in extracellular matrix
(ECM) deposition and vascular remodeling of distal pulmonary arteries. These changes …

Simple Summary In multiple sclerosis (MS), an autoimmune disease of the central nervous
system that primarily affects women, gender differences in disease course and in brain …

Drug discovery and toxicology is a complex process that involves considerable basic
research and preclinical evaluation. These depend highly on animal testing which often fails …

Cell alignment and elongation in the direction of anisotropic and aligned topographies are
key manifestations of cellular contact guidance and are observed in many cell types …