Mesenchymal condensation in tooth development and regeneration: a focus on translational aspects of organogenesis

BD Sui, CX Zheng, WM Zhao, K Xuan… - Physiological …, 2023 - journals.physiology.org
The teeth are vertebrate-specific, highly specialized organs performing fundamental
functions of mastication and speech, the maintenance of which is crucial for orofacial …

Associating growth factor secretions and transcriptomes of single cells in nanovials using SEC-seq

S Udani, J Langerman, D Koo, S Baghdasarian… - Nature …, 2024 - nature.com
Cells secrete numerous bioactive molecules that are essential for the function of healthy
organisms. However, scalable methods are needed to link individual cell secretions to their …

DLP printed hDPSC-loaded GelMA microsphere regenerates dental pulp and repairs spinal cord

Y Qian, J Gong, K Lu, Y Hong, Z Zhu, J Zhang, Y Zou… - Biomaterials, 2023 - Elsevier
Dental pulp regeneration is ideal for irreversible pulp or periapical lesions, and in situ stem
cell therapy is one of the most effective therapies for pulp regeneration. In this study, we …

Determinants of dental pulp stem cell heterogeneity

S Nel, C Durandt, C Murdoch, MS Pepper - Journal of Endodontics, 2022 - Elsevier
Introduction The aim of this review is to provide a narrative review on the determinants of
dental pulp stem cell (DPSC) heterogeneity that may affect the regenerative properties of …

BDNF/TrkB is a crucial regulator in the inflammation-mediated odontoblastic differentiation of dental pulp stem cells

JH Kim, M Irfan, MA Hossain, A George, S Chung - Cells, 2023 - mdpi.com
The odontoblastic differentiation of dental pulp stem cells (DPSCs) associated with caries
injury happens in an inflammatory context. We recently demonstrated that there is a link …

Wnt3a‐Loaded Hydroxyapatite Nanowire@ Mesoporous Silica Core− Shell Nanocomposite Promotes the Regeneration of Dentin− Pulp Complex via Angiogenesis …

N Luo, YW Deng, J Wen, XC Xu… - Advanced …, 2023 - Wiley Online Library
Pulp exposure often leads to pulp necrosis, root fractures, and ultimate tooth loss. The repair
of the exposure site with pulp capping treatment is of great significance to preserving pulp …

Single‐cell RNA sequencing in oral science: Current awareness and perspectives

J Wu, Y Ding, J Wang, F Lyu, Q Tang, J Song… - Cell …, 2022 - Wiley Online Library
The emergence of single‐cell RNA sequencing enables simultaneous sequencing of
thousands of cells, making the analysis of cell population heterogeneity more efficient. In …

Chronological and Replicative Aging of CD51+/PDGFR-α+ Pulp Stromal Cells

L Yao, F Li, C Yu, H Wang, Y Wang… - Journal of Dental …, 2023 - journals.sagepub.com
As a crucial source of mesenchymal stromal cells, CD51+/PDGFR-α+ human dental pulp
stromal cells (hDPSCs) are promising seeding cells for regenerative medicine. Cellular …

Osteoinductive Dental Pulp Stem Cell-Derived Extracellular Vesicle-Loaded Multifunctional Hydrogel for Bone Regeneration

L Wang, X Wei, X He, S Xiao, Q Shi, P Chen, J Lee… - ACS …, 2024 - ACS Publications
Stem cell-derived extracellular vesicles (EVs) show great potential for promoting bone tissue
regeneration. However, normal EVs (Nor-EVs) have a limited ability to direct tissue-specific …

A review with updated perspectives on in vitro and in vivo wound healing models

MN Sarian, N Zulkefli, S ZAIN… - Turkish Journal of …, 2023 - journals.tubitak.gov.tr
A skin wound or perforation triggers a series of homeostatic reactions to safeguard internal
organs from invasion by pathogens or other substances that could damage body tissues. An …