The prevalence of dementia is increasing in our aging population at an alarming rate.
Because of the heterogeneity of clinical presentation and complexity of disease …

Although epilepsy as a comorbidity in neurodegenerative disorders is increasingly
recognized, its incidence is still underestimated and the features of epilepsy in the different …

Tau protein aggregates in several neurodegenerative disorders, referred to as tauopathies.
The tau isoforms observed in post mortem human brain aggregates is used to classify …

Objective Dementias and mild cognitive impairment (MCI) are associated with variously
combined changes in the neurotransmitter system and signaling, from neurotransmitter …

Dementia—a syndrome affecting human cognition—is a major public health concern given
to its rising prevalence worldwide. Though multiple research studies have analyzed …

The rising prevalence of progressive neurodegenerative diseases coupled with increasing
longevity poses an economic burden at individual and societal levels. There is currently no …

We investigated whether pharmacological increase of “M-type”(KCNQ, Kv7) K+ channel
currents by the M-channel opener, retigabine (RTG), acutely after repetitive traumatic brain …

Background and purpose Chronic traumatic encephalopathy (CTE) is a neurodegenerative
disease occurring most commonly in athletes and is caused by repeated concussive or …

Arrestins are multifunctional proteins that regulate G-protein-coupled receptor (GPCR)
desensitization, signaling, and internalization. The arrestin family consists of four subtypes …

TDP-43 proteinopathy is a salient neuropathologic feature in a subset of frontotemporal
lobar degeneration (FTLD-TDP), in amyotrophic lateral sclerosis (ALS-TDP), and in limbic …