Objective: Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy
associated with repeated subconcussive and concussive head injury. Clinical features …

Purpose Huntington's disease (HD) is a monogenic neurodegenerative disease with no
effective treatment currently available. The pathological hallmark of HD is the aggregation of …

Exosomes are nanosized “off-the-shelf” lipid vesicles released by almost all cell types and
play a significant role in cell–cell communication. Exosomes have already been proven to …

The diagnosis of dementia is challenging and early stages are rarely detected limiting the
possibilities for early intervention. Another challenge is the overlap in the clinical features …

Concussion is defined as a complex pathophysiological process that affects the brain as a
result of traumatic biomechanical forces. Repeated unrecovered concussions can result in …

Due to the growing number of chronic traumatic encephalopathy (CTE) cases in the military
and contact sports, defining the cellular and molecular substrate of this disorder is crucial …

Background Frontotemporal dementia (FTD) is the second leading cause of early onset
dementia following Alzheimer's disease. It involves atrophy of the frontal and temporal …

Sir2/Sirt1 and its orthologues are known lifespan extension factors in several aging models
from yeast to invertebrates. Sirt1 activation is also known to be beneficial and protective in …

Though not as well-known as Alzheimer's disease, yet with a prevalence of 15–22/100,000,
and an incidence 2.7–4.1/100,000 cases per year, frontotemporal dementia is a grave …

Casein Kinase 1 isoform δ (CK1δ) belongs to Protein Kinase (PK) superfamily and it is
involved in several cellular processes and in neurodegenerative disorders including …