The tau protein aggregates in several neurodegenerative disorders, referred to as
tauopathies. The type of tau isoforms (4R/3R) observed in brain aggregates is used to …

Amyotrophic lateral sclerosis (ALS) is a genetically heterogeneous neurodegenerative
disease in which 97% of patients exhibit cytoplasmic aggregates containing the RNA …

Background: FTD is the second commonest presentation of early onset dementia after AD.
While the clinical features, pathophysiology and genetics of FTD are heterogeneous, AD is a …

Due to the growing number of chronic traumatic encephalopathy (CTE) cases in the military
and contact sports, defining the cellular and molecular substrate of this disorder is crucial …

Frontotemporal lobar degeneration (FTLD) is a leading cause of early-onset dementia, but
the pathological mechanisms underlying this disorder are not well understood. Common …

I was given the task of reviewing current knowledge on Alzheimer's disease. Each of us,
professional clinician, is daily confronted with cases and persons of disparate origin who …

Self-aggregation of proteins and peptides is at the root of many diseases, especially
neurodegenerative diseases. These conditions include Alzheimer's disease, Huntington's …

Amyotrophic lateral sclerosis (ALS) is a severe, progressive and incurable motor disease
that is characterized by death of motor neurons in the brain and spinal cord, resulting in a …

Amyotrophic lateral sclerosis (ALS) is a severe, progressive and incurable motor disease.
Roughly 20% of the ALS patients are affected by a level of cognitive decline that meets the …

Alzheimer's Disease (AD) and Frontotemporal Dementia (FTD) are the leading causes of
early onset dementia. There are currently no ways to slow down progression, to prevent or …