[HTML][HTML] Pharmacogenetics of type 2 diabetes—progress and prospects

YA Nasykhova, ZN Tonyan, AA Mikhailova… - International Journal of …, 2020 - mdpi.com
Type 2 diabetes mellitus (T2D) is a chronic metabolic disease resulting from insulin
resistance and progressively reduced insulin secretion, which leads to impaired glucose …

The gut microbial endocrine organ in type 2 diabetes

W Massey, JM Brown - Endocrinology, 2021 - academic.oup.com
Historically, the focus of type II diabetes mellitus (T2DM) research has been on host
metabolism and hormone action. However, emerging evidence suggests that the gut …

Microbial-driven genetic variation in holobionts

I Zilber-Rosenberg, E Rosenberg - FEMS Microbiology Reviews, 2021 - academic.oup.com
Genetic variation in holobionts (host and microbiome), occurring in both host and
microbiome genomes, can be observed from two perspectives: observable variations and …

[HTML][HTML] Long-term treatment of polysaccharides-based hydrogel microparticles as oral insulin delivery in streptozotocin-induced type 2 diabetic mice

Y Yang, S Chen, Y Liu, Y Huang, KL Cheong… - Biomedicine & …, 2021 - Elsevier
To develop a more effective and safer drug for the treatment of type 2 diabetes mellitus
(T2DM), polysaccharides-based hydrogel microparticles as oral insulin delivery was …

Evolution of Bioinformatics and its impact on modern bio-science in the twenty-first century: Special attention to pharmacology, plant science and drug discovery

D Mitra, D Mitra, MS Bensaad, S Sinha, K Pant… - Computational …, 2022 - Elsevier
Bioinformatics is inherently an innovative field that is situated at the limit of life and computer
sciences that allowed new technological advances in genome sequencing, data processing …

[HTML][HTML] Predicting type 2 diabetes via machine learning integration of multiple omics from human pancreatic islets

T Rönn, A Perfilyev, N Oskolkov, C Ling - Scientific Reports, 2024 - nature.com
Abstract Type 2 diabetes (T2D) is the fastest growing non-infectious disease worldwide.
Impaired insulin secretion from pancreatic beta-cells is a hallmark of T2D, but the …

[HTML][HTML] Genetic perspectives on childhood monogenic diabetes: Diagnosis, management, and future directions

HY Sun, XY Lin - World Journal of Diabetes, 2023 - ncbi.nlm.nih.gov
Monogenic diabetes is caused by one or even more genetic variations, which may be
uncommon yet have a significant influence and cause diabetes at an early age. Monogenic …

[HTML][HTML] Recent progress in the diagnosis and management of type 2 diabetes mellitus in the era of COVID-19 and single cell multi-omics technologies

K Kupai, T Várkonyi, S Török, V Gáti, Z Czimmerer… - Life, 2022 - mdpi.com
Type 2 diabetes mellitus (T2DM) is one of the world's leading causes of death and life-
threatening conditions. Therefore, we review the complex vicious circle of causes …

[HTML][HTML] Diabetes: discovery of insulin, genetic, epigenetic and viral infection mediated regulation

S Ghosh, S Mahalanobish, PC Sil - The Nucleus, 2021 - Springer
Diabetes mellitus, commonly referred to as diabetes, is a combination of many metabolic
diseases. Insulin deficiency in our body is the main cause of diabetes. Insulin is one of the …

[HTML][HTML] A 646C> G (rs41423247) polymorphism of the glucocorticoid receptor as a risk factor for hyperglycaemia diagnosed in pregnancy—data from an …

A Zawiejska, A Bogacz, R Iciek, A Lewicka-Rabska… - Acta Diabetologica, 2021 - Springer
Aim Hyperglycaemia diagnosed in pregnancy (HiP) is a serious and frequent complication
of pregnancy, increasing the risk for adverse maternal and neonatal outcomes. Investigate …