RNA-binding proteins (RBPs) are of fundamental importance for post-transcriptional gene
regulation and protein synthesis. They are required for pre-mRNA processing and for RNA …

Summary mRNA in eukaryotic cells is packaged into highly compacted ribonucleoprotein
particles (mRNPs) in the nucleus and exported to the cytoplasm for translation. mRNP …

Transport of mRNAs is an important step of gene expression, which brings the genetic
message from the DNA in the nucleus to a precise cytoplasmic location in a regulated …

The yeast THO complex is recruited to active genes and interacts with the RNA-dependent
ATPase Sub2 to facilitate the formation of mature export-competent messenger …

RNA-binding proteins (RBPs) control every RNA metabolic process by multiple protein–RNA
and protein–protein interactions. Their roles have largely been analyzed by crude mutations …

The eukaryotic mRNA life cycle includes transcription, nuclear mRNA export and
degradation. To quantify all these processes simultaneously, we perform thiol-linked …

RNA-binding proteins (RBPs) interact with mRNA to form supramolecular complexes called
messenger ribonucleoprotein (mRNP) particles. These dynamic assemblies direct and …

The templating RNA is the core of the telomerase reverse transcriptase. In Saccharomyces
cerevisiae, the complex life cycle and maturation of telomerase includes a cytoplasmic …

The passage of mRNAs through the nuclear pores into the cytoplasm is essential in all
eukaryotes. For regulation, mRNA export is tightly connected to the full machinery of nuclear …

Endoplasmic Reticulum (ER) stress, caused by the accumulation of misfolded proteins in the
ER, elicits a homeostatic mechanism known as the Unfolded Protein Response (UPR). The …