DNA methylation-based predictors of health: applications and statistical considerations
DNA methylation data have become a valuable source of information for biomarker
development, because, unlike static genetic risk estimates, DNA methylation varies …
development, because, unlike static genetic risk estimates, DNA methylation varies …
Epigenetics of type 2 diabetes mellitus and weight change—a tool for precision medicine?
Pioneering studies performed over the past few decades demonstrate links between
epigenetics and type 2 diabetes mellitus (T2DM), the metabolic disorder with the most …
epigenetics and type 2 diabetes mellitus (T2DM), the metabolic disorder with the most …
Determinants of body fat distribution in humans may provide insight about obesity-related health risks
AP Frank, R de Souza Santos, BF Palmer… - Journal of lipid …, 2019 - ASBMB
Obesity increases the risks of developing cardiovascular and metabolic diseases and
degrades quality of life, ultimately increasing the risk of death. However, not all forms of …
degrades quality of life, ultimately increasing the risk of death. However, not all forms of …
The applications and mechanisms of superoxide dismutase in medicine, food, and cosmetics
M Zheng, Y Liu, G Zhang, Z Yang, W Xu, Q Chen - Antioxidants, 2023 - mdpi.com
Superoxide dismutase (SOD) is a class of enzymes that restrict the biological oxidant cluster
enzyme system in the body, which can effectively respond to cellular oxidative stress, lipid …
enzyme system in the body, which can effectively respond to cellular oxidative stress, lipid …
Reference-free deconvolution of DNA methylation data and mediation by cell composition effects
Background Recent interest in reference-free deconvolution of DNA methylation data has
led to several supervised methods, but these methods do not easily permit the interpretation …
led to several supervised methods, but these methods do not easily permit the interpretation …
Epigenetic modification of nucleic acids: from basic studies to medical applications
The epigenetic modification of nucleic acids represents one of the most significant areas of
study in the field of nucleic acids because it makes gene regulation more complex and …
study in the field of nucleic acids because it makes gene regulation more complex and …
Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium
GC Sharp, LA Salas, C Monnereau… - Human molecular …, 2017 - academic.oup.com
Pre-pregnancy maternal obesity is associated with adverse offspring outcomes at birth and
later in life. Individual studies have shown that epigenetic modifications such as DNA …
later in life. Individual studies have shown that epigenetic modifications such as DNA …
Recent developments on the role of epigenetics in obesity and metabolic disease
The increased prevalence of obesity and related comorbidities is a major public health
problem. While genetic factors undoubtedly play a role in determining individual …
problem. While genetic factors undoubtedly play a role in determining individual …
The role of DNA methylation in cardiovascular risk and disease: methodological aspects, study design, and data analysis for epidemiological studies
Epidemiological studies have demonstrated that genetic, environmental, behavioral, and
clinical factors contribute to cardiovascular disease development. How these risk factors …
clinical factors contribute to cardiovascular disease development. How these risk factors …
[HTML][HTML] DNA methylation in the pathogenesis of type 2 diabetes in humans
Abstract Background Type 2 diabetes (T2D) is a multifactorial, polygenic disease caused by
impaired insulin secretion and insulin resistance. Genome-wide association studies (GWAS) …
impaired insulin secretion and insulin resistance. Genome-wide association studies (GWAS) …