Diverse molecular species of sulfatide with differences in FA lengths, unsaturation degrees,
and hydroxylation statuses are expressed in the kidneys. However, the physiological …

To elucidate the physiologic function of renal globotriaosylceramide (Gb3/CD77), which up-
to-date has been associated exclusively with Shiga toxin binding, we have analyzed renal …

Owing to its capability of discriminating subtle mass-altering structural differences such as
double bonds or elongated acyl chains, MALDI-based imaging MS (IMS) has emerged as a …

Obesity was reported to cause kidney injury by excessive accumulation of sphingolipids
such as sphingomyelin and ceramide. Sphingomyelin synthase 2 (SMS2) is an important …

Remarkably little is known about nitrogenous excretion in freshwater invertebrates. In the
current study, the nitrogen excretion mechanism in the carnivorous ribbon leech …

Mammalian kidneys are rich in sulfatides. Papillary sulfatides, especially, contribute to renal
adaptation to chronic metabolic acidosis. Due to differences in their ceramide (Cer) anchors …

Renal cell carcinoma (RCC) is the deadliest primary genitourinary malignancy typically
associated with asymptomatic initial presentation and poorly predictable survival. Next to …

Ammonium, stemming from renal ammoniagenesis, is a major urinary proton buffer and is
excreted along the collecting duct. This process depends on the concomitant secretion of …

Sphingolipids (SLs) regulate apoptosis, proliferation, and stress response. SLs, including
ceramide, glycosphingolipids (glucosylceramide, lactosylceramide, and gangliosides) and …

Crystallins were firstly found as structural proteins of the eye lens. To this family belong
proteins, such as ζ-crystallin, expressed ubiquitously, and endowed with enzyme activity. ζ …