Methods and applications for single-cell and spatial multi-omics
K Vandereyken, A Sifrim, B Thienpont… - Nature Reviews Genetics, 2023 - nature.com
The joint analysis of the genome, epigenome, transcriptome, proteome and/or metabolome
from single cells is transforming our understanding of cell biology in health and disease. In …
from single cells is transforming our understanding of cell biology in health and disease. In …
Beyond assembly: the increasing flexibility of single-molecule sequencing technology
The maturation of high-throughput short-read sequencing technology over the past two
decades has shaped the way genomes are studied. Recently, single-molecule, long-read …
decades has shaped the way genomes are studied. Recently, single-molecule, long-read …
scGPT: toward building a foundation model for single-cell multi-omics using generative AI
Generative pretrained models have achieved remarkable success in various domains such
as language and computer vision. Specifically, the combination of large-scale diverse …
as language and computer vision. Specifically, the combination of large-scale diverse …
Droplet-based single-cell joint profiling of histone modifications and transcriptomes
Abstract We previously reported Paired-Tag, a combinatorial indexing-based method that
can simultaneously map histone modifications and gene expression at single-cell resolution …
can simultaneously map histone modifications and gene expression at single-cell resolution …
Advancing CAR T cell therapy through the use of multidimensional omics data
Despite the notable success of chimeric antigen receptor (CAR) T cell therapies in the
treatment of certain haematological malignancies, challenges remain in optimizing CAR …
treatment of certain haematological malignancies, challenges remain in optimizing CAR …
A fast, scalable and versatile tool for analysis of single-cell omics data
Single-cell omics technologies have revolutionized the study of gene regulation in complex
tissues. A major computational challenge in analyzing these datasets is to project the large …
tissues. A major computational challenge in analyzing these datasets is to project the large …
Interpreting non-coding disease-associated human variants using single-cell epigenomics
Genome-wide association studies (GWAS) have linked hundreds of thousands of sequence
variants in the human genome to common traits and diseases. However, translating this …
variants in the human genome to common traits and diseases. However, translating this …
Integration of spatial and single-cell data across modalities with weakly linked features
Although single-cell and spatial sequencing methods enable simultaneous measurement of
more than one biological modality, no technology can capture all modalities within the same …
more than one biological modality, no technology can capture all modalities within the same …
New genetic and epigenetic insights into the chemokine system: The latest discoveries aiding progression toward precision medicine
H Xu, S Lin, Z Zhou, D Li, X Zhang, M Yu… - Cellular & Molecular …, 2023 - nature.com
Over the past thirty years, the importance of chemokines and their seven-transmembrane G
protein-coupled receptors (GPCRs) has been increasingly recognized. Chemokine …
protein-coupled receptors (GPCRs) has been increasingly recognized. Chemokine …
The heterocellular heart: identities, interactions, and implications for cardiology
The heterocellular nature of the heart has been receiving increasing attention in recent
years. In addition to cardiomyocytes as the prototypical cell type of the heart, non-myocytes …
years. In addition to cardiomyocytes as the prototypical cell type of the heart, non-myocytes …