Understanding the causality of the post-traumatic osteoarthritis (PTOA) disease process of
the knee joint is important for diagnosing early disease and developing new and effective …

Inflammation plays a central role in the pathogenesis of knee PTOA after knee trauma. While
a comprehensive therapy capable of preventing or delaying post-traumatic osteoarthritis …

Traumatic injuries of the knee joint result in a wide variety of pathomechanisms, which
contribute to the development of so-called posttraumatic osteoarthritis (PTOA). These …

Accumulation of senescent chondrocytes is thought to drive inflammatory processes and
subsequent cartilage degeneration in age-related as well as posttraumatic osteoarthritis …

Osteoarthritis (OA) affects more than 500 million people worldwide and is among the five
diseases in Germany causing the highest suffering of the patients and cost for the society …

Osteoarthritis (OA) is a common musculoskeletal disease that leads to deterioration of
articular cartilage, joint pain, and decreased quality of life. When OA develops after a joint …

The incidence of musculoskeletal diseases is steadily increasing with aging of the
population. In the past years, extracellular vesicles (EVs) have gained attention in …

Disc degeneration and vertebral endplate bone marrow lesions called Modic changes are
prevalent spinal pathologies found in chronic low back pain patients. Their …

Purpose The complement system is a crucial part of innate immunity. Recent work
demonstrated an unexpected contribution to tissue homeostasis and degeneration. This …

Purpose Formation of terminal complement complex (TCC), a downstream complement
system activation product inducing inflammatory processes and cell lysis, has been …