Molecular mechanisms and clinical application of multipotent stem cells for spinal cord injury

M Szymoniuk, J Litak, L Sakwa, A Dryla, W Zezuliński… - Cells, 2022 - mdpi.com
Spinal Cord Injury (SCI) is a common neurological disorder with devastating psychical and
psychosocial sequelae. The majority of patients after SCI suffer from permanent disability …

Emerging exosomes and exosomal MiRNAs in spinal cord injury

J Feng, Y Zhang, Z Zhu, C Gu, A Waqas… - Frontiers in cell and …, 2021 - frontiersin.org
Acute spinal cord injury (SCI) is a serious traumatic event to the spinal cord with
considerable morbidity and mortality. This injury leads to short-and long-term variations in …

[HTML][HTML] The role of PI3K/Akt signalling pathway in spinal cord injury

CL Xiao, WC Yin, YC Zhong, JQ Luo, LL Liu… - Biomedicine & …, 2022 - Elsevier
Spinal cord injury (SCI) is a severely disabling central nervous system injury with complex
pathological mechanisms that leads to sensory and motor dysfunction. The current treatment …

Current concepts of biomaterial scaffolds and regenerative therapy for spinal cord injury

H Suzuki, Y Imajo, M Funaba, H Ikeda… - International Journal of …, 2023 - mdpi.com
Spinal cord injury (SCI) is a catastrophic condition associated with significant neurological
deficit and social and financial burdens. It is currently being managed symptomatically, with …

Exosomes derived from human placental mesenchymal stem cells enhanced the recovery of spinal cord injury by activating endogenous neurogenesis

W Zhou, M Silva, C Feng, S Zhao, L Liu, S Li… - Stem cell research & …, 2021 - Springer
Background Spinal cord injury (SCI) is a debilitating medical condition that can result in the
irreversible loss of sensorimotor function. Current therapies fail to provide an effective …

Exosome-shuttled miR-672-5p from anti-inflammatory microglia repair traumatic spinal cord injury by inhibiting AIM2/ASC/Caspase-1 signaling pathway mediated …

Z Zhou, C Li, T Bao, X Zhao, W Xiong, C Luo… - Journal of …, 2022 - liebertpub.com
Traumatic spinal cord injury (TSCI) is a devastating traumatic disease of the central nervous
system, which leads to refractory loss of motor and sensory function. So far, there is no …

Bone marrow mesenchymal stem cells and exercise restore motor function following spinal cord injury by activating PI3K/AKT/mTOR pathway

X Sun, LY Huang, HX Pan, LJ Li, L Wang… - Neural regeneration …, 2023 - journals.lww.com
Although many therapeutic interventions have shown promise in treating spinal cord injury,
focusing on a single aspect of repair cannot achieve successful and functional regeneration …

Multimodal treatment for spinal cord injury: a sword of neuroregeneration upon neuromodulation

Y Zheng, YR Mao, TF Yuan, DS Xu… - Neural regeneration …, 2020 - journals.lww.com
Spinal cord injury is linked to the interruption of neural pathways, which results in
irreversible neural dysfunction. Neural repair and neuroregeneration are critical goals and …

Three-dimensional bioprinting collagen/silk fibroin scaffold combined with neural stem cells promotes nerve regeneration after spinal cord injury

JP Jiang, XY Liu, F Zhao, X Zhu, XY Li… - Neural regeneration …, 2020 - journals.lww.com
Many studies have shown that bio-scaffolds have important value for promoting axonal
regeneration of injured spinal cord. Indeed, cell transplantation and bio-scaffold implantation …

Stem cells therapy for spinal cord injury: an overview of clinical trials

S Silvestro, P Bramanti, O Trubiani… - International Journal of …, 2020 - mdpi.com
Spinal cord injury (SCI) is a traumatic lesion that causes disability with temporary or
permanent sensory and/or motor deficits. The pharmacological approach still in use for the …