[HTML][HTML] Advanced approaches to regenerate spinal cord injury: the development of cell and tissue engineering therapy and combinational treatments

J Saremi, N Mahmoodi, M Rasouli, FE Ranjbar… - Biomedicine & …, 2022 - Elsevier
Spinal cord injury (SCI) is a central nervous system (CNS) devastate event that is commonly
caused by traumatic or non-traumatic events. The reinnervation of spinal cord axons is …

[HTML][HTML] Fabrication techniques of nerve guidance conduits for nerve regeneration

NU Kang, SJ Lee, SJ Gwak - Yonsei medical journal, 2022 - ncbi.nlm.nih.gov
Neuronal loss and axonal degeneration after spinal cord injury or peripheral injury result in
the loss of sensory and motor functions. Nerve regeneration is a complicated and medical …

Differentiation of human adipose-derived stem cells into neuron/motoneuron-like cells for cell replacement therapy of spinal cord injury

S Gao, X Guo, S Zhao, Y Jin, F Zhou, P Yuan… - Cell death & …, 2019 - nature.com
Human adipose-derived stem cells (hADSCs) are increasingly presumed to be a
prospective stem cell source for cell replacement therapy in various degenerative and/or …

Repeated subarachnoid administrations of allogeneic human umbilical cord mesenchymal stem cells for spinal cord injury: a phase 1/2 pilot study

Y Yang, M Pang, C Du, ZY Liu, ZH Chen, NX Wang… - Cytotherapy, 2021 - Elsevier
Background aims Stem cell transplantation is a potential treatment for intractable spinal cord
injury (SCI), and allogeneic human umbilical cord mesenchymal stem cells (hUC-MSCs) are …

Nrf2 activation: involvement in central nervous system traumatic injuries. a promising therapeutic target of natural compounds

S Silvestro, E Mazzon - International journal of molecular sciences, 2022 - mdpi.com
Central nervous system (CNS) trauma, such as traumatic brain injury (TBI) and spinal cord
injury (SCI), represents an increasingly important health burden in view of the preventability …

Applications of nanomaterials for scavenging reactive oxygen species in the treatment of central nervous system diseases

Z An, J Yan, Y Zhang, R Pei - Journal of Materials Chemistry B, 2020 - pubs.rsc.org
Reactive oxygen species (ROS) are the key signaling molecules in many physiological
processes and play an important role in the development and function of the central nervous …

[HTML][HTML] Clinical trials in traumatic spinal cord injury

J Donovan, S Kirshblum - Neurotherapeutics, 2018 - Elsevier
Traumatic spinal cord injury (SCI) results in impaired neurologic function that for many
individuals is permanent and significantly impacts health, function, quality of life, and life …

Microglia-Derived Exosomal microRNA-151-3p Enhances Functional Healing After Spinal Cord Injury by Attenuating Neuronal Apoptosis via Regulating the p53/p21 …

C Li, T Qin, Y Liu, H Wen, J Zhao, Z Luo… - Frontiers in cell and …, 2022 - frontiersin.org
Spinal cord injury (SCI) is a catastrophic event mainly involving neuronal apoptosis and
axonal disruption, and it causes severe motor and sensory deficits. Due to the complicated …

Hydrogel and nanomedicine‐based multimodal therapeutic strategies for spinal cord injury

P Yin, W Liang, B Han, Y Yang, D Sun, X Qu… - Small …, 2024 - Wiley Online Library
Spinal cord injury (SCI) is a severe neurodegenerative disease caused by mechanical and
biological factors, manifesting as a loss of motor and sensory functions. Inhibition of injury …

Vagus nerve stimulation reduces neuroinflammation through microglia polarization regulation to improve functional recovery after spinal cord injury

H Chen, Z Feng, L Min, W Deng, M Tan… - Frontiers in …, 2022 - frontiersin.org
Background Spinal cord injury (SCI) is a devastating disease that lacks effective treatment.
Interestingly, recent studies indicated that vagus nerve stimulation (VNS), neuromodulation …