Stroke is the leading cause of disability and thesecond leading cause of death worldwide.
With the global population aged 65 and over growing faster than all other age groups, the …

Intrapartum-related events are the third leading cause of childhood mortality worldwide and
result in one million neurodisabled survivors each year. Infants exposed to a perinatal insult …

Remote ischaemic conditioning (RIC) triggers endogenous protective pathways in distant
organs such as the kidney, heart and brain, and represents an exciting new paradigm in …

Lipoxygenase (5-LOX) inhibitors have been shown to be protective in several
neurodegenerative disease models; however, the underlying mechanisms remain unclear …

Cerebral ischemia-reperfusion (IR) has attracted wide attention as a serious clinical
problem. So far, the field has accumulated a large amount of scientific research literature. To …

Background and purpose Ischemic stroke activates Toll-like receptors (TLRs), triggering
rapid inflammatory cytokine production. Axl signaling has multiple roles, including regulating …

In the area of brain injury and neurodegenerative diseases, a plethora of experimental and
clinical evidence strongly indicates the promise of therapeutically exploiting the endogenous …

Novel and innovative approaches are essential in developing new treatments and improving
clinical outcomes in patients with ischemic stroke. Remote ischemic conditioning (RIC) is a …

Remote ischemic conditioning (RIC) is a promising therapeutic approach for ischemic stroke
patients. It has been proven that RIC reduces infarct size and improves functional outcomes …

Tumor necrosis factor receptor-associated factor (TRAF) is an important binding protein of
tumor necrosis factor (TNF) superfamily and the toll/IL-1 receptor (TIR) superfamily, which …