RNA sequencing identifies clonal structure of T-cell repertoires in patients with adult T-cell leukemia/lymphoma

A Farmanbar, R Kneller, S Firouzi - NPJ genomic medicine, 2019 - nature.com
The diversity of T-cell receptor (TCR) repertoires, as generated by somatic DNA
rearrangements, is central to immune system function. High-throughput sequencing …

Tumor-associated macrophage or chemokine ligand CCL17 positively regulates the tumorigenesis of hepatocellular carcinoma

F Zhu, X Li, S Chen, Q Zeng, Y Zhao, F Luo - Medical oncology, 2016 - Springer
Alternatively activated macrophages (M2) can secrete chemokines, such as chemokine
ligand 17 (CCL17), and are associated with promoting tumorigenesis of hepatocellular …

Early application of related SCT might improve clinical outcome in adult T-cell leukemia/lymphoma

S Fuji, H Fujiwara, N Nakano, A Wake… - Bone marrow …, 2016 - nature.com
Allogeneic hematopoietic SCT (allo-HSCT) is a curative treatment for aggressive adult T-cell
leukemia/lymphoma (ATLL). Considering the dismal prognosis associated with conventional …

Feed-forward regulatory loop driven by IRF4 and NF-κB in adult T-cell leukemia/lymphoma

RWJ Wong, TK Tan, S Amanda… - Blood, The Journal …, 2020 - ashpublications.org
Adult T-cell leukemia/lymphoma (ATL) is a highly aggressive hematological malignancy
derived from mature CD4+ T-lymphocytes. Here, we demonstrate the transcriptional …

IRF4 drives clonal evolution and lineage choice in a zebrafish model of T-cell lymphoma

S Amanda, TK Tan, JZL Ong, MS Theardy… - Nature …, 2022 - nature.com
IRF4 is a master regulator of immunity and is also frequently overexpressed in mature
lymphoid neoplasms. Here, we demonstrate the oncogenicity of IRF4 in vivo, its potential …

Dimethyl fumarate suppresses the proliferation of HTLV-1-infected T cells by inhibiting CBM complex-triggered NF-B signaling

T Sato, T Maeta, S Ito - Anticancer Research, 2023 - ar.iiarjournals.org
Background/Aim: Adult T-cell leukemia (ATL) is a peripheral T-lymphocytic malignancy
influenced by human T-cell leukemia virus type 1 (HTLV-1) infection. Aggressive ATL has a …

Prognostic index for chronic-and smoldering-type adult T-cell leukemia-lymphoma

H Katsuya, M Shimokawa, K Ishitsuka… - Blood, The Journal …, 2017 - ashpublications.org
Adult T-cell leukemia-lymphoma (ATL) has been divided into 4 clinical subtypes: acute,
lymphoma, chronic, and smoldering. The aim of this study is to develop a novel prognostic …

[HTML][HTML] Progress in allogeneic hematopoietic cell transplantation in adult T-cell leukemia-lymphoma

A Utsunomiya - Frontiers in microbiology, 2019 - frontiersin.org
The prognosis of aggressive adult T-cell leukemia-lymphoma (ATL) remains poor because
of frequent infections and drug resistance. Dose-intensified chemotherapy followed by …

PD-1 tumor suppressor signaling in T cell lymphomas

T Wartewig, J Ruland - Trends in immunology, 2019 - cell.com
The inhibitory receptor PD-1 is critical to balancing antigen-induced T cell activation; its
inhibition is currently being explored to enhance antitumor T cell immunity with certain …

Identification of joint gene players implicated in the pathogenesis of HTLV-1 and BLV through a comprehensive system biology analysis

F Ashrafi, SA Ghezeldasht, MZ Ghobadi - Microbial pathogenesis, 2021 - Elsevier
Background Human T-cell lymphotropic virus type 1 (HTLV-1) and bovine leukemia virus
(BLV) are oncogenic viruses that induce adult T cell leukemia/lymphoma (ATLL) and …