Intensive research during recent years has made the rodent liver one of the best model
systems to study chemical carcinogenesis and tumor promotion in vivo. As will be shown in …

A fully referenced, comprehensive scientific and technical report presenting the 1998 AMAP
assessment on the status of the Arctic environment with respect to pollution, including …

Publisher Summary The investigation of nutritional and other environmentally derived
influences in animal experiments has established that vast arrays of compounds are …

The effects of malachite green (MG) and pbenobarbitone (PB) were compared on the
development of pre-neoplastk lesions during N-nitrosodiethylamine (DEN)-induced hepato …

Hexachlorobenzene (HCB), an epigenetic carcinogen, HCB induces the formation of liver
tumors in female rats, whereas only a small percentage of males are responsive …

Hexachlorobenzene (HCB) was fed to male and female F344 rats as 0.02% of the diet for 15
weeks. Females developed a massive porphyria, due to depression of uroporphyrinogen …

Abstract α-, β-, and γ-hexachlorocyclohexane (α-, β-, γ-HCH) isomers are widespread
environmental pollutants; α-HCH can cause liver tumors in rats and mice. In the present …

By-products of disinfection were tested for initiating and/or promoting activity in rat liver by
using the rat liver foci bioassay. The assay uses an increased incidence of gamma …

This review describes the pathogenesis and significance of chemically-induced
hepatocellular altered foci in rat liver. The measurement of induction of foci can be used for …

Male and female F 344 rats were dosed every other day for 103 days with 50 μmole of
hexachlorobenzene (HCB)/kg. Females developed a hepatic porphyria, the urine and liver …