Crosstalk between Nrf2 signaling pathway and inflammation in ischemic stroke: mechanisms of action and therapeutic implications
One of the major causes of long-term disability and mortality is ischemic stroke that enjoys
limited treatment approaches. On the one hand, oxidative stress, induced by excessive …
limited treatment approaches. On the one hand, oxidative stress, induced by excessive …
Tanshinone-IIA mediated neuroprotection by modulating neuronal pathways
K Sherawat, S Mehan - Naunyn-Schmiedeberg's Archives of …, 2023 - Springer
The progression of neurological diseases is mainly attributed to oxidative stress, apoptosis,
inflammation, and trauma, making them a primary public concern. Since no drugs can stop …
inflammation, and trauma, making them a primary public concern. Since no drugs can stop …
Puerarin inhibited oxidative stress and alleviated cerebral ischemia-reperfusion injury through PI3K/Akt/Nrf2 signaling pathway
Q Zhang, M Yao, J Qi, R Song, L Wang, J Li… - Frontiers in …, 2023 - frontiersin.org
Introduction: Puerarin (PUE) is a natural compound isolated from Puerariae Lobatae Radix,
which has a neuroprotective effect on IS. We explored the therapeutic effect and underlying …
which has a neuroprotective effect on IS. We explored the therapeutic effect and underlying …
Tanshinone IIA inhibits ischemia-reperfusion-induced inflammation, ferroptosis and apoptosis through activation of the PI3K/Akt/mTOR pathway
R Zhang, Y Liu, J You, B Ge - Human & Experimental …, 2023 - journals.sagepub.com
Ischemia-reperfusion (I/R) is a common clinical process, and the lung is one of the most
sensitive organs of I/R injury, which often leads to acute lung injury (ALI). Tanshinone IIA …
sensitive organs of I/R injury, which often leads to acute lung injury (ALI). Tanshinone IIA …
Tanshinone ⅡA participates in the treatment of endometriosis by regulating adhesion, invasion, angiogenesis and inhibition of PI3K/Akt/mTOR signaling pathway
X Zhang, S Li, Z Chen, W Liang… - Molecular …, 2023 - spandidos-publications.com
Endometriosis (EMs) is a common gynecological disorder characterized by abnormal growth
of the endometrial stroma and glands outside the uterus. Tanshinone IIA, the active …
of the endometrial stroma and glands outside the uterus. Tanshinone IIA, the active …
丹参酮IIA 治疗缺血性脑卒中后神经损伤的信号通路研究进展
秦文秀, 许军峰, 杨婷, 王坪霏 - 中国临床药理学与治疗学, 2023 - manu41.magtech.com.cn
丹参酮IIA 是传统中药丹参发挥药理作用的主要活性成分之一, 经现代研究证实具有抗缺血性脑
卒中后神经损伤作用. 本文通过检索文献, 梳理近年来丹参酮IIA 作用于缺血性脑卒中后神经损伤 …
卒中后神经损伤作用. 本文通过检索文献, 梳理近年来丹参酮IIA 作用于缺血性脑卒中后神经损伤 …
Multiomics profiling of the therapeutic effect of dan-deng-tong-nao capsule on cerebral ischemia-reperfusion injury
Y Shi, Q Du, Z Li, L Xue, Q Jia, T Zheng, J Liu, R Ren… - Phytomedicine, 2024 - Elsevier
Background Stroke is a complex physiological process associated with intestinal flora
dysbiosis and metabolic disorders. Dan-deng-tong-nao capsule (DDTN) is a traditional …
dysbiosis and metabolic disorders. Dan-deng-tong-nao capsule (DDTN) is a traditional …
Mechanism of neocryptotanshinone in protecting against cerebral ischemic injury: by suppressing M1 polarization of microglial cells and promoting cerebral …
L Zhai, H Pei, H Shen, Q Guan, J Sheng - International …, 2023 - Elsevier
Aim This study explored the protective function and mechanism of neocryptotanshinone
(NEO) on cerebral ischemia. Methods Lipopolysaccharide/γ-interferon (LPS/IFN-γ) was …
(NEO) on cerebral ischemia. Methods Lipopolysaccharide/γ-interferon (LPS/IFN-γ) was …
Pharmacological Actions of Tanshinone IIA with Special Focus on Nrf-2 Signaling Pathway
Abstract Salvia miltiorrhiza Bunge, Lamiaceae, widely recognized as “danshen,” Chinese
sage, is an important long-established traditional Chinese medication, and tanshinone IIA is …
sage, is an important long-established traditional Chinese medication, and tanshinone IIA is …
Puerarin alleviates acrolein‐induced atherosclerosis by activating the MYH9‐mediated SIRT1/Nrf2 cascade to inhibit the activation of inflammasome
XN Li, YT Li, HH Jiao, AT Wang… - Biotechnology and …, 2024 - Wiley Online Library
Puerarin (Pue) has significant antioxidant and anti‐inflammatory properties. This work was
designed to clarify and investigate the potential mechanisms of Pue in atherosclerosis (AS) …
designed to clarify and investigate the potential mechanisms of Pue in atherosclerosis (AS) …