Since the identification of the first disease causing mutation in the gene coding for emerin, a
transmembrane protein of the inner nuclear membrane, hundreds of mutations and variants …

Since the discovery of the inner nuclear transmembrane protein emerin in the early 1990s,
nuclear envelope (NE) components and related involvement in nuclei integrity and …

DYT1 dystonia is a hereditary neurologic movement disorder characterized by
uncontrollable muscle contractions. It is caused by a heterozygous mutation in Torsin A …

Optimal cell performance depends on cell size and the appropriate relative size, ie, scaling,
of the nucleus. How nuclear scaling is regulated and contributes to cell function is poorly …

While the transcription factor NEUROD2 has recently been associated with epilepsy, its
precise role during nervous system development remains unclear. Using a multi-scale …

The development and maintenance of neuromuscular junctions (NMJ) are supported by a
specialized population of myonuclei that are referred to as the subsynaptic myonuclei …

The ɸC31 integrase system is widely used in Drosophila melanogaster to allow transgene
targeting to specific loci. Over the years, flies bearing any of more than 100 attP docking …

Across species, sleep in young animals is critical for normal brain maturation. The molecular
determinants of early life sleep remain unknown. Through an RNAi-based screen, we …

DYT1 dystonia is a debilitating neurological movement disorder, and it represents the most
frequent and severe form of hereditary primary dystonia. There is currently no cure for this …

A null mutation of the Drosophila calcium/calmodulin-dependent protein kinase II gene
(CaMKII) was generated using homologous recombination. Null animals survive to larval …