Therapeutic role of mesenchymal stem cell-derived extracellular vesicles in female reproductive diseases

Z Liao, C Liu, L Wang, C Sui, H Zhang - Frontiers in endocrinology, 2021 - frontiersin.org
Reproductive disorders, including intrauterine adhesion (IUA), premature ovarian
insufficiency (POI), and polycystic ovary syndrome (PCOS), are great threats to female …

Role of miRNAs interference on ovarian functions and premature ovarian failure

N Nouri, O Shareghi-Oskoue, L Aghebati-Maleki… - Cell Communication and …, 2022 - Springer
Premature ovarian failure is a to some extent unknown and intricate problem with diverse
causes and clinical manifestations. The lack of ovarian sex hormones presumably is …

BNC1 deficiency-triggered ferroptosis through the NF2-YAP pathway induces primary ovarian insufficiency

F Wang, Y Liu, F Ni, J Jin, Y Wu, Y Huang, X Ye… - Nature …, 2022 - nature.com
Primary ovarian insufficiency (POI) is a clinical syndrome of ovarian dysfunction
characterized by premature exhaustion of primordial follicles. POI causes infertility, severe …

[HTML][HTML] miR-484 mediates oxidative stress-induced ovarian dysfunction and promotes granulosa cell apoptosis via SESN2 downregulation

X Wang, J Yang, H Li, H Mu, L Zeng, S Cai, P Su, H Li… - Redox Biology, 2023 - Elsevier
Ovarian dysfunction is a common cause of female infertility, which is associated with genetic,
autoimmune and environmental factors. Granulosa cells (GCs) constitute the largest cell …

Ensemble of kernel ridge regression-based small molecule–miRNA association prediction in human disease

CC Wang, CC Zhu, X Chen - Briefings in Bioinformatics, 2022 - academic.oup.com
MicroRNAs (miRNAs) play crucial roles in human disease and can be targeted by small
molecule (SM) drugs according to numerous studies, which shows that identifying SM …

Advanced Oxidation Protein Products Induce G1/G0‐Phase Arrest in Ovarian Granulosa Cells via the ROS‐JNK/p38 MAPK‐p21 Pathway in Premature Ovarian …

XY Zhou, J Zhang, Y Li, YX Chen… - Oxidative Medicine …, 2021 - Wiley Online Library
The mechanism underlying the role of oxidative stress and advanced oxidation protein
products (AOPPs) in the aetiology of premature ovarian insufficiency (POI) is poorly …

[HTML][HTML] Ammonium ferric citrate induced ferroptosis in non-small-cell lung carcinoma through the inhibition of GPX4-GSS/GSR-GGT axis activity

W Wu, Z Geng, H Bai, T Liu, B Zhang - International journal of …, 2021 - ncbi.nlm.nih.gov
The morbidity and mortality rates associated with non-small-cell lung carcinoma (NSCLC)
are increasing every year, placing new demands on existing therapies and drugs …

MicroRNA‐146b‐5p overexpression attenuates premature ovarian failure in mice by inhibiting the Dab2ip/Ask1/p38‐Mapk pathway and γH2A. X phosphorylation

T Liu, J Lin, C Chen, X Nie, F Dou, J Chen… - Cell …, 2021 - Wiley Online Library
Objective To examine the role of high‐fat and high‐sugar (HFHS) diet‐induced oxidative
stress, which is a risk factor for various diseases, in premature ovarian failure (POF) …

Human Amniotic Fluid Mesenchymal Stem Cell‐Derived Exosomes Inhibit Apoptosis in Ovarian Granulosa Cell via miR‐369‐3p/YAF2/PDCD5/p53 Pathway

Z Geng, H Chen, G Zou, L Yuan, P Liu… - Oxidative medicine …, 2022 - Wiley Online Library
Human amniotic fluid stem cell‐derived exosome (HuAFSC‐exosome) transplantation is
considered a promising treatment for premature ovarian failure (POF). However, its …

microRNAs in female infertility: An overview

S Bahmyari, Z Jamali, SH Khatami… - Cell Biochemistry …, 2021 - Wiley Online Library
Infertility impacts a considerable number of women worldwide, and it affects different aspects
of family life and society. Although female infertility is known as a multifactorial disorder …