Current therapeutic approaches for Parkinson's disease (PD) are based around treatments
that alleviate symptoms but do not slow or prevent disease progression. As such, alternative …

Mitochondrial dysfunction and oxidative stress are strongly implicated in Parkinson's
disease (PD) pathogenesis and there is evidence that mitochondrially-generated …

Mitochondria are essential for neuronal function. They produce ATP to meet energy
demands, regulate homeostasis of ion levels such as calcium and regulate reactive oxygen …

Gene-environment interaction is implicated in the majority of idiopathic Parkinson's disease
(PD) risk, and some of the most widespread environmental contaminants are selectively …

Parkinson's disease (PD) is a progressive neurodegenerative disorder affecting millions of
people worldwide. Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) are …

Individuals with Parkinson's disease (PD) typically receive a diagnosis once they have
developed motor symptoms, at which point there is already significant loss of substantia …

Parkinson's Disease (PD) affects millions of people worldwide with no cure to halt the
progress of the disease. Leucine-rich repeat kinase 2 (LRRK2) is the most common genetic …

Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are progressive
neurodegenerative diseases characterized by the accumulation of misfolded α-synuclein in …

The catecholamine neurotransmitter dopamine has the potential to act as an endogenous
neurotoxin when its vesicular sequestration is dysregulated. Despite postmortem analyses …

Organic solvents are common chemicals used in industry throughout the world, however,
there is evidence for adverse health effects from exposure to these compounds …