Cellular stress induced by the abnormal accumulation of unfolded or misfolded proteins at
the endoplasmic reticulum (ER) is emerging as a possible driver of human diseases …

Neuronal cell death occurs extensively during development and pathology, where it is
especially important because of the limited capacity of adult neurons to proliferate or be …

The clinical manifestation of neurodegenerative diseases is initiated by the selective
alteration in the functionality of distinct neuronal populations. The pathology of many …

Endoplasmic reticulum (ER) stress is transmitted to mitochondria and is associated with
pathologic mitochondrial dysfunction in diverse diseases. The PERK arm of the unfolded …

Neuronal protein synthesis is essential for long-term memory consolidation, and its
dysregulation is implicated in various neurodegenerative disorders, including Alzheimer's …

Traumatic brain injury (TBI) is a leading cause of long-term neurological disability, yet the
mechanisms underlying the chronic cognitive deficits associated with TBI remain unknown …

Alzheimer's disease (AD), the most common form of dementia in late life, will become even
more prevalent by midcentury, constituting a major global health concern with huge …

Perturbed neuronal proteostasis is a salient feature shared by both aging and protein
misfolding disorders. The proteostasis network controls the health of the proteome by …

Altered proteostasis is a salient feature of Alzheimer's disease (AD), highlighting the
occurrence of endoplasmic reticulum (ER) stress and abnormal protein aggregation. ER …

Background In preclinical studies, p38⍺ kinase is implicated in Alzheimer's disease (AD)
pathogenesis. In animal models, it mediates impaired synaptic dysfunction in the …