Recent progress in machine learning approaches for predicting carcinogenicity in drug development

NQK Le, TX Tran, PA Nguyen, TT Ho… - Expert Opinion on Drug …, 2024 - Taylor & Francis
Introduction This review explores the transformative impact of machine learning (ML) on
carcinogenicity prediction within drug development. It discusses the historical context and …

[HTML][HTML] Gold nanoparticles attenuate the interferon-γ induced SOCS1 expression and activation of NF-κB p65/50 activity via modulation of microRNA-155-5p in triple …

A Farhana, A Alsrhani, N Rasheed… - Frontiers in …, 2023 - frontiersin.org
Objective Triple-negative breast cancer (TNBC) is a very aggressive form of cancer that
grows and spreads very fast and generally relapses. Therapeutic options of TNBC are …

[HTML][HTML] Gold Nanoparticles Downregulate IL-6 Expression/Production by Upregulating microRNA-26a-5p and Deactivating the RelA and NF-κBp50 Transcription …

A Farhana, A Alsrhani, RS Alghsham, W Derafa… - International Journal of …, 2024 - mdpi.com
MicroRNAs (miRNAs) are involved in the modulation of pathogenic genes by binding to their
mRNA sequences'3′ untranslated regions (3′ UTR). Interleukin-6 (IL-6) is known to …

[HTML][HTML] Mitochondrial–Stem Cell Connection: Providing Additional Explanations for Understanding Cancer

P Martinez, I Baghli, G Gourjon, TN Seyfried - Metabolites, 2024 - mdpi.com
The cancer paradigm is generally based on the somatic mutation model, asserting that
cancer is a disease of genetic origin. The mitochondrial–stem cell connection (MSCC) …

Unraveling the Complexity of Immune Checkpoint Modulation in Gastrointestinal Malignancies

M Shoaib, HM Haseeb, K Bano… - Pak-Euro Journal of …, 2023 - readersinsight.net
Gastrointestinal cancers are accountable for the highest mortality rates on a global scale,
including gastric adenocarcinomas and hepatocellular carcinoma on a large scale. Tumor …

[PDF][PDF] Immunotherapy Influence On Human Body: Glycan Engineering Antibody-Based Cancer Treatments

KM Bakare, AM Nkeiruka, UO Matthew… - J Comm Med and Pub …, 2024 - academia.edu
Abstract Analysis of cells, soluble substances, and related tissues and cells that cooperate to
extend life continues to awaken researchers' curiosity. Because of its incredible complexity …

Repurposing mitochondrial-targeting anthelmintic agents with GLUT1 inhibitor BAY-876 for cancer therapy

TJ Schumacher, AV Iyer, J Rumbley, CT Ronayne… - bioRxiv, 2024 - biorxiv.org
Cancer cells alter their metabolic phenotypes with nutritional change. Single agent
approaches targeting mitochondrial metabolism in cancer have failed due to either dose …

[引用][C] Aisha Farhana1, Abdullah Alsrhani1, Naila Rasheed2, 3 and Zafar Rasheed4

N Yusuf, SM Aghaei-Zarch, S Shyamasundar… - 2023 - europepmc.org
Objective: Triple-negative breast cancer (TNBC) is a very aggressive form of cancer that
grows and spreads very fast and generally relapses. Therapeutic options of TNBC are …