The inner ear comprises four epithelial domains: the cochlea, vestibule, semicircular canals,
and endolymphatic duct/sac. These structures are segregated at embryonic day 13.5 (E13 …

Abstract Small Rho GTPases such as Cdc42 and Rac1 regulate peripheral myelination
during development. Deletion of Rac1 in Schwann cell conditional knockout mice causes a …

Rac small GTPases play important roles during embryonic development of the inner ear;
however, little is known regarding their function in cochlear hair cells (HCs) after …

Our sense of hearing is critically dependent on the spiral ganglion neurons (SGNs) that
connect the sound receptors in the organ of Corti (OC) to the cochlear nuclei of the …

Cisplatin, a utilized anticancer drug in clinical practice, induces sensorineural hearing loss
(SNHL) in patients. However, the precise mechanism underlying cisplatin-associated …

Biomedical research findings are typically disseminated through publications. To simplify
access to domain specific knowledge while supporting the research community, several …

The inventors have identified an autosomal dominant (AD) missense mutation in the RAC2
gene (coding for Ras-related botulinum toxin substrate 2 (RAC2)) in three Severe combined …

In the mammalian organ of Corti (OC), planar polarity of individual auditory hair cells is
defined by their V-shaped hair bundle. At the tissue level, all hair cells display uniform …

Cover image: A z-projection of a confocal image stack of phalloidin-labelled filamentous
actin in a mature mouse organ of Corti. Several outer hair cells have died due to a systemic …

Planar cell polarity (PCP) is a common feature of all tissues, and refers to the coordinated
orientation of cells and/or cellular structures in an axis parallel to the plane of a tissue …