B cell receptor-induced protein dynamics and the emerging role of SUMOylation revealed by proximity proteomics
LO Awoniyi, DM Cunha, AV Sarapulov… - Journal of cell …, 2023 - journals.biologists.com
Successful B cell activation, which is critical for high-affinity antibody production, is
controlled by the B cell antigen receptor (BCR). However, we still lack a comprehensive …
controlled by the B cell antigen receptor (BCR). However, we still lack a comprehensive …
APEX proximity labeling as a versatile tool for biological research
TMT Nguyen, J Kim, TT Doan, MW Lee, M Lee - Biochemistry, 2019 - ACS Publications
Most proteins are specifically localized in membrane-encapsulated organelles or non-
membrane-bound compartments. The subcellular localization of proteins facilitates their …
membrane-bound compartments. The subcellular localization of proteins facilitates their …
Proximity-dependent biotinylation approaches to explore the dynamic compartmentalized proteome
U Dionne, AC Gingras - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
In recent years, proximity-dependent biotinylation approaches, including BioID, APEX, and
their derivatives, have been widely used to define the compositions of organelles and other …
their derivatives, have been widely used to define the compositions of organelles and other …
[HTML][HTML] The Golgi complex: a hub of the secretory pathway
The Golgi complex plays a central role in protein secretion by regulating cargo sorting and
trafficking. As these processes are of functional importance to cell polarity, motility, growth …
trafficking. As these processes are of functional importance to cell polarity, motility, growth …
Succinate as a signaling molecule in the mediation of liver diseases
H Chen, C Jin, L Xie, J Wu - … et Biophysica Acta (BBA)-Molecular Basis of …, 2024 - Elsevier
Succinate, one of the intermediates of the tricarboxylic acid (TCA) cycle, plays an essential
role in the metabolism of mitochondria and the production of energy, and is considered as a …
role in the metabolism of mitochondria and the production of energy, and is considered as a …
Proximity labeling methods for proteomic analysis of membrane proteins
F Zafra, D Piniella - Journal of Proteomics, 2022 - Elsevier
Membrane proteins constitute the filter that controls the cellular traffic of nutrients, ions and
other essential molecules, as well as the transmission of signals across the membrane …
other essential molecules, as well as the transmission of signals across the membrane …
Spatially resolved phosphoproteomics reveals fibroblast growth factor receptor recycling-driven regulation of autophagy and survival
J Watson, HR Ferguson, RM Brady, J Ferguson… - Nature …, 2022 - nature.com
Abstract Receptor Tyrosine Kinase (RTK) endocytosis-dependent signalling drives cell
proliferation and motility during development and adult homeostasis, but is dysregulated in …
proliferation and motility during development and adult homeostasis, but is dysregulated in …
[HTML][HTML] Time-resolved proximity labeling of protein networks associated with ligand-activated EGFR
Ligand binding to the EGF receptor (EGFR) triggers multiple signal-transduction processes
and promotes endocytosis of the receptor. The mechanisms of EGFR endocytosis and its …
and promotes endocytosis of the receptor. The mechanisms of EGFR endocytosis and its …
Promoting validation and cross-phylogenetic integration in model organism research
KC Cheng, RD Burdine, ME Dickinson… - Disease models & …, 2022 - journals.biologists.com
Model organism (MO) research provides a basic understanding of biology and disease due
to the evolutionary conservation of the molecular and cellular language of life. MOs have …
to the evolutionary conservation of the molecular and cellular language of life. MOs have …
Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1
AK Luciano, ED Korobkina, SP Lyons, JA Haley… - Journal of Biological …, 2022 - ASBMB
Mechanistic target of rapamycin (mTOR) complex 2 (mTORC2) regulates metabolism, cell
proliferation, and cell survival. mTORC2 activity is stimulated by growth factors, and it …
proliferation, and cell survival. mTORC2 activity is stimulated by growth factors, and it …