Successful B cell activation, which is critical for high-affinity antibody production, is
controlled by the B cell antigen receptor (BCR). However, we still lack a comprehensive …

Most proteins are specifically localized in membrane-encapsulated organelles or non-
membrane-bound compartments. The subcellular localization of proteins facilitates their …

In recent years, proximity-dependent biotinylation approaches, including BioID, APEX, and
their derivatives, have been widely used to define the compositions of organelles and other …

The Golgi complex plays a central role in protein secretion by regulating cargo sorting and
trafficking. As these processes are of functional importance to cell polarity, motility, growth …

Succinate, one of the intermediates of the tricarboxylic acid (TCA) cycle, plays an essential
role in the metabolism of mitochondria and the production of energy, and is considered as a …

Membrane proteins constitute the filter that controls the cellular traffic of nutrients, ions and
other essential molecules, as well as the transmission of signals across the membrane …

Abstract Receptor Tyrosine Kinase (RTK) endocytosis-dependent signalling drives cell
proliferation and motility during development and adult homeostasis, but is dysregulated in …

Ligand binding to the EGF receptor (EGFR) triggers multiple signal-transduction processes
and promotes endocytosis of the receptor. The mechanisms of EGFR endocytosis and its …

Model organism (MO) research provides a basic understanding of biology and disease due
to the evolutionary conservation of the molecular and cellular language of life. MOs have …

Mechanistic target of rapamycin (mTOR) complex 2 (mTORC2) regulates metabolism, cell
proliferation, and cell survival. mTORC2 activity is stimulated by growth factors, and it …