Chronotherapeutics aim at treating illnesses according to the endogenous biologic rhythms,
which moderate xenobiotic metabolism and cellular drug response. The molecular clocks …

The goal of this review article is to assess how relevant is the concept of dissipative structure
for understanding the dynamical bases of non-equilibrium self-organization in biological …

Higher-order networks have emerged as a powerful framework to model complex systems
and their collective behavior. Going beyond pairwise interactions, they encode structured …

Inferring the structure and dynamics of network models is critical to understanding the
functionality and control of complex systems, such as metabolic and regulatory biological …

One of the major challenges in modern biology is to understand how the molecular
components of a living cell operate in a highly noisy environment. What are the specific …

Impairment of the circadian clock has been associated with numerous disorders, including
metabolic disease. Although small molecules that modulate clock function might offer …

An introduction to the mathematical concepts and techniques needed for the construction
and analysis of models in molecular systems biology. Systems techniques are integral to …

Circadian control of cell division is well established in diverse organisms. Recent single-cell
studies on mouse fibroblasts have shown that the circadian clock and cell cycle systems are …

Background: The pattern of somites is traced out by a mechanism involving oscillating gene
expression at the tail end of the embryo. In zebrafish, two linked oscillating genes, her1 and …

Molecular mechanisms of the mammalian circadian clock have been studied primarily by
genetic perturbation and behavioral analysis. Here, we used bioluminescence imaging to …