Cryptococcosis

EK Maziarz, JR Perfect - Infectious disease clinics, 2016 - id.theclinics.com
Cryptococcosis is an infectious disease with worldwide distribution and wide array of clinical
presentations caused by pathogenic encapsulated yeasts in the genus Cryptococcus …

A holistic review on Cryptococcus neoformans

SS Rathore, J Sathiyamoorthy, C Lalitha… - Microbial …, 2022 - Elsevier
Cryptococcus neoformans is an encapsulated fungal pathogen that causes infection in
immunocompromised individuals such as HIV patients, organ transplant patients …

Mechanisms of fungal dissemination

AB Strickland, M Shi - Cellular and Molecular Life Sciences, 2021 - Springer
Fungal infections are an increasing threat to global public health. There are more than six
million fungal species worldwide, but less than 1% are known to infect humans. Most of …

Toll-like receptor 4 and macrophage scavenger receptor 1 crosstalk regulates phagocytosis of a fungal pathogen

CU Onyishi, GE Desanti, AL Wilkinson… - Nature …, 2023 - nature.com
The opportunistic fungal pathogen Cryptococcus neoformans causes lethal infections in
immunocompromised patients. Macrophages are central to the host response to cryptococci; …

Cryptococcal cell morphology affects host cell interactions and pathogenicity

LH Okagaki, AK Strain, JN Nielsen, C Charlier… - PLoS …, 2010 - journals.plos.org
Cryptococcus neoformans is a common life-threatening human fungal pathogen. The size of
cryptococcal cells is typically 5 to 10 µm. Cell enlargement was observed in vivo, producing …

Fungal cell gigantism during mammalian infection

O Zaragoza, R García-Rodas, JD Nosanchuk… - PLoS …, 2010 - journals.plos.org
The interaction between fungal pathogens with the host frequently results in morphological
changes, such as hyphae formation. The encapsulated pathogenic fungus Cryptococcus …

Phagosome extrusion and host-cell survival after Cryptococcus neoformans phagocytosis by macrophages

M Alvarez, A Casadevall - Current Biology, 2006 - cell.com
Cryptococcus neoformans (Cn) is an encapsulated yeast that is a facultative intracellular
pathogen and a frequent cause of human disease. The interaction of Cn with alveolar …

Cryptococcus neoformans Intracellular Proliferation and Capsule Size Determines Early Macrophage Control of Infection

A Bojarczuk, KA Miller, R Hotham, A Lewis… - Scientific reports, 2016 - nature.com
Cryptococcus neoformans is a significant fungal pathogen of immunocompromised patients.
Many questions remain regarding the function of macrophages in normal clearance of …

Capsule enlargement in Cryptococcus neoformans confers resistance to oxidative stress suggesting a mechanism for intracellular survival

O Zaragoza, CJ Chrisman, MV Castelli… - Cellular …, 2008 - Wiley Online Library
Cryptococcus neoformans is a facultative intracellular pathogen. The most distinctive feature
of C. neoformans is a polysaccharide capsule that enlarges depending on environmental …

Essential Role for Neutrophils but not Alveolar Macrophages at Early Time Points following Aspergillus fumigatus Infection

MM Mircescu, L Lipuma, N Van Rooijen… - The Journal of …, 2009 - academic.oup.com
Alveolar macrophages and neutrophils mediate innate immune defense against the
opportunistic fungal pathogen Aspergillus fumigatus and are believed to be essential for …