Sleep-immune interactions are well-known phenomena in everyday life and folk wisdom.
There is no doubt that an infection makes us tired and increases the desire to sleep, and a …

This review provides an overview of the clinical issue of poorly controlled postoperative pain
and therapeutic approaches that may help to address this common unresolved health-care …

Importance Prescription opioid analgesics play an important role in the treatment of
postoperative pain; however, unused opioids may be diverted for nonmedical use and …

Pain can be both a cause and a consequence of sleep deficiency. This bidirectional
relationship between sleep and pain has important implications for clinical management of …

Worldwide, the use of prescription opioid analgesics more than doubled between 2001 and
2013, with several countries, including the USA, Canada, and Australia, experiencing …

Inadequate perioperative pain is, unfortunately, frequent, and has clinically relevant
consequences, including decreased patient satisfaction, delayed postoperative mobilization …

Objective To quantify the effects of varying opioid prescribing patterns after surgery on
dependence, overdose, or abuse in an opioid naive population. Design Retrospective …

It has long been appreciated that individuals differ from each other in important ways. More
than 2000 years ago, Plato said:“No 2 persons are born exactly alike; but each differs from …

Postoperative pain has been poorly managed for decades. Recent surveys from USA and
Europe do not show any major improvement. Persistent postoperative pain is common after …

Background: Many studies have analyzed risk factors for the development of severe
postoperative pain with contradictory results. To date, the association of risk factors with …