Inflammation plays an important role in the response to danger signals arising from damage
to our body and in restoring homeostasis. Dysregulated inflammatory responses occur in …

Executive summary The number of older people, including those living with dementia, is
rising, as younger age mortality declines. However, the age-specific incidence of dementia …

Sleep is a biological necessity, and insufficient sleep and untreated sleep disorders are
detrimental for health, well-being, and public safety. Healthy People 2030 includes several …

Alzheimer's disease (AD) is the most common cause of dementia. The pathophysiology of
this disease is characterized by the accumulation of amyloid-β, leading to the formation of …

Endogenous biological clocks, orchestrated by the suprachiasmatic nucleus, time the
circadian rhythms that synchronize physiological and behavioural functions in humans. The …

The discovery of reciprocal connections between the central nervous system, sleep and the
immune system has shown that sleep enhances immune defences and that afferent signals …

Importance Older adults with insomnia have a high risk of incident and recurrent depression.
Depression prevention is urgently needed, and such efforts have been neglected for older …

Polysomnography (PSG) studies of sleep changes in Alzheimer's disease (AD) have
reported but not fully established the relationship between sleep disturbances and AD. To …

Sleep duration, psychiatric disorders and dementias are closely interconnected in older
adults. However, the underlying genetic mechanisms and brain structural changes are …

Alzheimer's disease is one of the most commonly diagnosed cases of senile dementia in the
world. It is an incurable process, most often leading to death. This disease is multifactorial …