We recently demonstrated increased dendritic cells (potent antigen-presenting cells) and
MCP-1 (monocyte, T-cell, and dendritic cell attracting chemokine) levels in ALS spinal cord …

Oxidative stress mediated by nitric oxide (NO) and its toxic metabolite peroxynitrite has
previously been associated with motor neuron degeneration in amyotrophic lateral sclerosis …

Research into amyotrophic lateral sclerosis (ALS) has been stimulated by a series of genetic
and molecular pathology discoveries. The hallmark neuronal cytoplasmic inclusions of …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with an adult onset
characterized by loss of both upper and lower motor neurons. In~ 10% of cases, patients …

Oxidative stress over time leads to the accumulation of damaged macromolecules and to
profound physiological changes that are associated with several age-related diseases. The …

[Frontiers in Bioscience 9, 763-776, January 1, 2004] 763 NITRIC OXIDE NEUROTOXICITY IN
NEURODEGENERATIVE DISEASES Kathleen MK Page 1 [Frontiers in Bioscience 9, 763-776 …

The accumulation of misfolded or unfolded proteins in the endoplasmic reticulum (ER)
lumen causes a cellular stress response termed the unfolded protein response. Although ER …

Periventricular leukomalacia (PVL) is the major substrate of cerebral palsy in survivors of
prematurity. Its pathogenesis is complex and likely involves ischemia/reperfusion in the …

Manganese—salen complexes (Mn-Salen), including EUK-8 [manganese N, N′-bis
(salicylidene) ethylenediamine chloride] and EUK-134 [manganese 3-methoxy N, N′-bis …

The mechanisms of injury-and disease-related degeneration of motor neurons (MNs) need
clarification. Unilateral avulsion of the sciatic nerve in the mouse induces apoptosis of spinal …