Metabolic adaptation to viral infections critically determines the course and manifestations of
disease. At the systemic level, a significant feature of viral infection and inflammation that …

Macrophages are the primary targets of Mycobacterium tuberculosis infection; the early
events of macrophage interaction with M. tuberculosis define subsequent progression and …

During chronic HIV infection, immune cells become increasingly dysfunctional and
exhausted. Little is known about how immune functions are restored after initiation of …

The gastrointestinal mucosa is critical for maintaining the integrity and functions of the gut.
Disruption of this barrier is a hallmark and a risk factor for many intestinal and chronic …

Immunometabolism, the study of the relationship between bioenergetic pathways and
specific functions of immune cells, has recently gained increasing appreciation. In response …

Non-invasive biomarkers that predict HIV remission after antiretroviral therapy (ART)
interruption are urgently needed. Such biomarkers can improve the safety of analytic …

The HIV/AIDS (human immunodeficiency virus/acquired immunodeficiency syndrome) and
tuberculosis (TB) pandemics are perpetuated by a significant global burden of HIV/TB co …

Pulmonary hypertension (PH) is an often-fatal vascular disease of unclear molecular origins.
The pulmonary vascular remodelling which occurs in PH is characterised by elevated …

Introduction People living with HIV (PLWH) on antiretroviral therapy (ART) do not progress to
AIDS. However, they still suffer from an increased risk of inflammation-associated …

Early HIV-1 infection is characterized by enhanced tryptophan catabolism, which contributes
to immune suppression and disease progression. However, the mechanism by which …